Ayadi Kabadou Ilhem, Soualmiaa Hayet, Jemaa Riadh, Feki Moncef, Kallel Ameni, Souheil Omar, Haj Taieb Sameh, Sanhaji Haifa, Kaabachi Naziha
Department of Biochemistry, Hospital la Rabta, Tunis, Tunisia.
Tunis Med. 2012 Aug-Sep;90(8-9):619-24.
Hypertension is a polygenic disease. Various singlenucleotide gene polymorphisms of renin angiotensin system have been explored in hypertension. Angiotensin II, the major biologically active component of this system, exerts its effect via two pharmacologically distinct subtypes of angiotensin II receptors, the angiotensin II type 1 receptor and the angiotensin II type 2 receptor.
To examine whether the 3123 C/A polymorphism of angiotensin II type 2 receptor gene is involved in hypertension in a sample of Tunisian population.
Atotal of 403 normotensive subjects and 382 hypertensive patients were included in the study. Genotyping was performed by polymerase chain reaction followed by Alu I restriction digestion.
The frequency of "A" genotype was not significantly different between the two groups in men (¯2=1.18; p=0.16). The estimated odds prevalence for hypertension ("A" versus "C") was 0.77 (95% CI 0.49 to 1.22, p=0.27). After adjustment for confounding factors, the OR for hypertension remained no significant (OR: 1.49, 95% CI: 0.84-2.63, p=0.16). In women, genotype distributions for C3123A variant in hypertensive patients were not significantly different from normotensive subjects (¯2=3.16; p=0.20). Multiple logistic regression analysis showed that the AA genotype was not significantly associated with hypertension (OR: 1.09, 95% CI: 0.58-2.06, p=0.77).
In the present study, we showed that the 3123 C/A polymorphism of AGT2R gene is not a significant factor for hypertension in a sample of Tunisian population.
高血压是一种多基因疾病。人们已经在高血压研究中探索了肾素血管紧张素系统的各种单核苷酸基因多态性。血管紧张素II是该系统的主要生物活性成分，它通过两种药理学上不同的血管紧张素II受体亚型发挥作用，即血管紧张素II 1型受体和血管紧张素II 2型受体。
在一组突尼斯人群样本中，研究血管紧张素II 2型受体基因3123 C/A多态性是否与高血压有关。
本研究共纳入403名血压正常者和382名高血压患者。采用聚合酶链反应及Alu I限制性酶切进行基因分型。
男性两组间“A”基因型频率无显著差异（χ²=1.18；p=0.16）。高血压的估计优势患病率（“A”与“C”相比）为0.77（95%可信区间0.49至1.22，p=0.27）。在对混杂因素进行校正后，高血压的比值比仍无显著性（比值比：1.49，95%可信区间：0.84 - 2.63，p=0.16）。在女性中，高血压患者C3123A变异的基因型分布与血压正常者无显著差异（χ²=3.16；p=0.20）。多因素logistic回归分析显示，AA基因型与高血压无显著相关性（比值比：1.09，95%可信区间：0.58 - 2.06，p=0.77）。
在本研究中，我们发现AGT2R基因3123 C/A多态性在突尼斯人群样本中不是高血压的显著影响因素。
