Department of Nephrology, Medical University of Graz, Austria.
Swiss Med Wkly. 2012 Sep 17;142:w13669. doi: 10.4414/smw.2012.13669. eCollection 2012.
Thyroid hormone is a central regulator of body functions. Disorders of thyroid function are considered to be a cause of electrolyte disorders. Only few data on the association between thyroid function and electrolyte disorders exists.
In the present retrospective analysis data from all patients admitted to the Department of Emergency Medicine of a university hospital who had measurements of thyroid function (TSH, fT(3), fT(4)) and electrolytes were included.
9,012 patients with measurement of TSH and electrolytes were available. 86% of patients had normal, 4% suppressed and 10% elevated TSH. Serum sodium was significantly lower in patients with high TSH levels (p <0.01). There was a significant correlation between serum TSH and phosphate level (p <0.05). Phosphate levels were higher in patients with elevated TSH than in patients with normal TSH (p <0.01). Serum calcium and magnesium correlated significantly with TSH (p <0.05). fT(3) levels correlated significantly with calcium (p <0.05). Hyponatraemia was present in 14% of patients with high TSH and was significantly more common than in the group with normal TSH levels of which 9% had hyponatraemia (p <0.01). Hypokalaemia was more common in the group with elevated TSH than in those with normal TSH (14 versus 11%, p = 0.016). Hyperkalaemia was more common in the group with high TSH levels (7%) than in those with normal TSH (7 vs. 4%, p <0.01).
An association between thyroid function and electrolyte disorders seems to exist, although it is probably only relevant in marked hypo-/hyperthyroidism.
甲状腺激素是身体功能的中枢调节剂。甲状腺功能障碍被认为是电解质紊乱的一个原因。只有少数关于甲状腺功能与电解质紊乱之间关系的数据。
本回顾性分析纳入了所有在大学医院急诊科就诊并测量甲状腺功能（TSH、fT(3)、fT(4)）和电解质的患者的数据。
共有 9012 名患者进行了 TSH 和电解质的测量。86%的患者 TSH 正常，4%的患者 TSH 受抑制，10%的患者 TSH 升高。高 TSH 水平患者的血清钠显著降低（p<0.01）。血清 TSH 与磷酸盐水平之间存在显著相关性（p<0.05）。TSH 升高的患者磷酸盐水平高于 TSH 正常的患者（p<0.01）。血清钙和镁与 TSH 显著相关（p<0.05）。fT(3)水平与钙显著相关（p<0.05）。高 TSH 患者中低钠血症的发生率为 14%，显著高于 TSH 正常组（9%）（p<0.01）。TSH 升高组低钾血症的发生率高于 TSH 正常组（14%比 11%，p=0.016）。高 TSH 组高钾血症的发生率高于 TSH 正常组（7%比 4%，p<0.01）。
甲状腺功能与电解质紊乱之间似乎存在关联，尽管这种关联可能仅与明显的甲状腺功能减退/亢进有关。
