Teni Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India.
Head Neck. 2013 Oct;35(10):1448-53. doi: 10.1002/hed.23153. Epub 2012 Sep 18.
We earlier observed altered expression of p53 and Bcl-xL in oral cancer cell lines/tissues and wanted to evaluate these proteins for prediction of radiotherapy response and outcome.
Thirty-nine paraffin-embedded, pretreatment oral cancer biopsies were analyzed for protein expression using immunohistochemistry and correlated with tumor response to radiotherapy and disease-free survival (DFS).
High p53 (p = .040) was observed in female versus male patients. Increased p53 intensity (p = .063) was observed in tobacco habitués (chewers ± smokers) versus patients with no habits. In univariate analysis, nodal positivity (p = .044) and favorable/complete tumor response (p = .002) exhibited a significant correlation with DFS, whereas tumor response emerged as an independent predictor of DFS in multivariate analysis. Significantly high Bcl-xL (p = .048) was observed in the unfavorable versus favorable responders.
Our study suggests that Bcl-xL expression along with clinical parameters may be useful for identifying patients with oral cancer likely to draw maximum benefit from curative radiotherapy.
我们先前观察到口腔癌细胞系/组织中 p53 和 Bcl-xL 的表达发生改变，我们希望评估这些蛋白以预测放疗反应和结果。
使用免疫组织化学分析了 39 例石蜡包埋的、治疗前的口腔癌活检组织中的蛋白表达情况，并与放疗反应和无病生存（DFS）进行了相关性分析。
女性患者中 p53 高表达（p =.040），有吸烟和咀嚼习惯的患者 p53 强度增加（p =.063）。单因素分析中，淋巴结阳性（p =.044）和肿瘤反应良好/完全（p =.002）与 DFS 显著相关，而肿瘤反应是多因素分析中 DFS 的独立预测因子。不良反应者 Bcl-xL 表达显著升高（p =.048）。
我们的研究表明，Bcl-xL 表达与临床参数结合可能有助于识别口腔癌患者，使他们从根治性放疗中获得最大益处。
