Jiangsu Key Laboratory for Carbon-Based, Functional Materials & Devices, Institute of Functional Nano & Soft, Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
Small. 2013 May 27;9(9-10):1492-503. doi: 10.1002/smll.201201417. Epub 2012 Sep 17.
Graphene, as a class of 2D carbon nanomaterial, has attracted tremendous interest in different areas in recent years including biomedicine. The toxicity and behavior of graphene in biological systems are thus important fundamental issues that require significant attention. In this article, the toxicity of graphene is reviewed by describing the behavior of graphene and its derivatives in microorganisms, cells, and animals. Despite certain inconsistencies in several detailed experimental results and hypotheses of toxicity mechanisms, results from numerous reports all agree that the physicochemical properties such as surface functional groups, charges, coatings, sizes, and structural defects of graphene may affect its in vitro/in vivo behavior as well as its toxicity in biological systems. It is hoped that this review article will provide an overview understanding of the impacts, behavior, and toxicology of graphene and its derivatives in various biological systems.
石墨烯作为一种二维碳纳米材料，近年来在包括生物医学在内的不同领域引起了极大的兴趣。因此，石墨烯在生物系统中的毒性和行为是需要引起高度关注的重要基础问题。本文通过描述石墨烯及其衍生物在微生物、细胞和动物中的行为，综述了石墨烯的毒性。尽管在一些详细的实验结果和毒性机制假说中存在一定的不一致，但来自大量报道的结果都一致认为，石墨烯的物理化学性质，如表面官能团、电荷、涂层、大小和结构缺陷，可能会影响其在体外/体内的行为以及在生物系统中的毒性。希望本文综述能为理解石墨烯及其衍生物在各种生物系统中的影响、行为和毒理学提供一个全面的认识。
