Ma Yufei, Shen He, Tu Xiaolong, Zhang Zhijun
CAS Key Laboratory for Nano-Bio Interface Research, Suzhou Key Laboratory of Nanobiomedicine, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech & Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
Nanomedicine (Lond). 2014 Jul;9(10):1565-80. doi: 10.2217/nnm.14.68.
Graphene, a novel 2D carbon nanomaterial with unique properties, has attracted massive attention. Evaluating its toxicity is of great significance due to its potential applications in many fields, especially in biomedicine. In this review, the toxicity of graphene-based nanomaterials (GNMs) and related mechanisms at the molecular and cellular level, various approaches to evaluation of the in vivo toxicity of GNMs and major factors defining their toxicity will be discussed and summarized. This review will allow better understanding of the in vitro and in vivo toxicity of GNMs, which, we believe, may facilitate design and fabrication of novel, biocompatible and efficient GNM-based systems for biomedical applications.
石墨烯是一种具有独特性质的新型二维碳纳米材料，已引起广泛关注。由于其在许多领域，特别是生物医学领域的潜在应用，评估其毒性具有重要意义。在本综述中，将讨论并总结基于石墨烯的纳米材料（GNMs）的毒性及其在分子和细胞水平的相关机制、评估GNMs体内毒性的各种方法以及决定其毒性的主要因素。本综述将有助于更好地理解GNMs的体外和体内毒性，我们相信这可能会促进用于生物医学应用的新型、生物相容性和高效的基于GNM的系统的设计和制造。
