过氧化物酶，连接衰老与基因组不稳定性和癌症的衰老基因。
Peroxiredoxins, gerontogenes linking aging to genome instability and cancer.
机构信息
Department of Cell and Molecular Biology, University of Gothenburg, Göteborg, Sweden.
出版信息
Genes Dev. 2012 Sep 15;26(18):2001-8. doi: 10.1101/gad.200006.112.
Abstract
Age is the highest risk factor known for a large number of maladies, including cancers. However, it is unclear how aging mechanistically predisposes the organism to such diseases and which gene products are the primary targets of the aging process. Recent studies suggest that peroxiredoxins, antioxidant enzymes preventing tumor development, are targets of age-related deterioration and that bolstering their activity (e.g., by caloric restriction) extends cellular life span. This review focuses on how the peroxiredoxin functions (i.e., as peroxidases, signal transducers, and molecular chaperones) fit with contemporary theories of aging and whether peroxiredoxins could be targeted therapeutically in the treatment of age-associated cancers.
摘要
年龄是许多疾病（包括癌症）的最大已知风险因素。然而，目前尚不清楚衰老在何种程度上使机体易患此类疾病，以及哪些基因产物是衰老过程的主要靶标。最近的研究表明，抗氧化酶过氧化物酶体在预防肿瘤发生方面发挥着重要作用，它们是与年龄相关的衰退的靶标，而增强它们的活性（例如，通过限制热量摄入）可以延长细胞寿命。这篇综述重点讨论了过氧化物酶体的功能（即作为过氧化物酶、信号转导物和分子伴侣）如何与衰老的现代理论相吻合，以及过氧化物酶体是否可以作为治疗与年龄相关的癌症的治疗靶点。
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