Cancer Information Service Division, Center for Cancer Control and Information Services, National Cancer Center, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.
Jpn J Clin Oncol. 2012 Nov;42(11):1008-12. doi: 10.1093/jjco/hys144. Epub 2012 Sep 17.
Breast cancer is the most common type of cancer in women worldwide. Although the incidence of breast cancer is still on an increasing trend, there are few studies concerning breast cancer risk factors in Japan. Therefore, we conducted an Internet survey investigating the prevalence of risk factors for breast cancer.
We conducted an Internet survey using opt-in panels in women aged from 20 to 70 years. The survey items consisted of potential and proven risk factors for breast cancer such as age at menarche, menopausal status, premenopausal use of oral contraceptives, postmenopausal use of hormones, parity, height, alcohol consumption and family history of breast cancer.
Subjects comprised 2002 persons who were matched for sex, age and residential area with the National Census in 2005. Statistically significant trends were observed for most factors: age at menarche is becoming lower, age at first birth is higher, height is higher, the proportion of women who have given birth is smaller and the proportion of women who drink alcohol is larger.
We showed a clear increase in the prevalence of risk factors for breast cancer. Based on the results, the incidence of breast cancer in Japan may be increasing for at least a few decades.
乳腺癌是全世界女性最常见的癌症类型。尽管乳腺癌的发病率仍呈上升趋势,但针对日本乳腺癌危险因素的研究较少。因此,我们进行了一项互联网调查,调查乳腺癌危险因素的流行情况。
我们使用 20-70 岁女性的自选小组进行了互联网调查。调查项目包括乳腺癌的潜在和已证实的危险因素,如初潮年龄、绝经状态、绝经前口服避孕药使用、绝经后激素使用、产次、身高、饮酒和乳腺癌家族史。
研究对象包括 2002 名与 2005 年全国人口普查在性别、年龄和居住地区相匹配的人。大多数因素都呈现出统计学意义上的显著趋势:初潮年龄越来越低,初产年龄越来越高,身高越来越高,生育过的女性比例越来越小,饮酒的女性比例越来越大。
我们显示了乳腺癌危险因素的流行率明显增加。基于这些结果,日本的乳腺癌发病率至少在未来几十年内可能会持续上升。