Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Greater Bay Area Cancer Registry, University of California San Francisco, San Francisco, CA, USA.
Cancer Causes Control. 2023 Mar;34(3):241-249. doi: 10.1007/s10552-022-01659-7. Epub 2022 Dec 11.
To characterize breast cancer (BC) incidence by age at diagnosis and BC subtype among disaggregated Asian American, Native Hawaiian, and Pacific Islander (AANHPI) women and non-Hispanic White (NHW) women in Hawai'i.
Using 1990-2014 data from the Hawai'i tumor registry, we estimated age-adjusted incidence rates (AAIR) of BC and the annual percent change in BC incidence by age (<50 and ≥50 years) and BC subtype (hormone receptor [HR]+/human epidermal growth factor receptor 2 [HER2]-, HR+/HER2+, HR-/HER2+, triple negative BC) for Filipino American (FA), Japanese American (JA), Native Hawaiian (NH), and NHW women.
Among young (<50 years) women, annual BC incidence increased 2.9% (1994-2014) among JA and 1.0% (1990-2014) among NHW women. Incidence was highest among young JA women (2010-2014 AAIR 52.0 per 100,000; 95% confidence interval [CI] 45.6, 58.9). HR+/HER2- BC, the major BC subtype, was similarly highest among young JA women (AAIR 39.5; 95% CI 33.9, 45.4). Among older (≥50 years) women, annual BC incidence increased 1.6% (1990-2014) among FA and 4.2% (2006-2014) for JA women. BC incidence was highest among older NH women (AAIR 137.6, 95% CI 128.2, 147.4), who also displayed highest incidence of two subtypes: HR+/HER2- (AAIR 106.9; 95% CI 98.6, 115.5) and HR+/HER2+ (AAIR 12.1; 95% CI 9.4, 15.1).
We observed high and increasing BC incidence among JA women ages <50 years and high incidence among NH women ages ≥50 years. These results highlight racial and ethnic differences in BC incidence among disaggregated AANHPI populations in Hawai'i by age and BC subtype.
描述按诊断年龄和乳腺癌亚型分类的亚裔美国、夏威夷原住民和太平洋岛民（AANHPI）以及非西班牙裔白人（NHW）女性乳腺癌（BC）发病率特征。
利用 1990-2014 年来自夏威夷肿瘤登记处的数据，我们估计了各年龄段（<50 岁和≥50 岁）和乳腺癌亚型（激素受体[HR]+/人表皮生长因子受体 2 [HER2]-、HR+/HER2+、HR-/HER2+、三阴性乳腺癌）的乳腺癌发病率（AAIR）和乳腺癌发病率的年变化百分比（1994-2014 年在日裔美国人 [JA]中增加 2.9%，在 NHW 女性中增加 1.0%）。在年轻 (<50 岁) 女性中，JA 女性的年度乳腺癌发病率最高（2010-2014 年 AAIR 为 52.0/100,000；95%置信区间 [CI] 45.6，58.9）。HR+/HER2-乳腺癌是主要的乳腺癌亚型，在年轻的 JA 女性中发病率也最高（AAIR 39.5；95%CI 33.9，45.4）。在年龄较大的（≥50 岁）女性中，1990-2014 年 FA 女性的年度 BC 发病率增长 1.6%，2006-2014 年 JA 女性增长 4.2%。年龄较大的 NH 女性的 BC 发病率最高（AAIR 137.6，95%CI 128.2，147.4），她们也表现出两种亚型的最高发病率：HR+/HER2-（AAIR 106.9；95%CI 98.6，115.5）和 HR+/HER2+（AAIR 12.1；95%CI 9.4，15.1）。
我们观察到 JA 女性<50 岁的 BC 发病率高且呈上升趋势，NH 女性≥50 岁的 BC 发病率高。这些结果突出了夏威夷 AANHPI 人群按年龄和乳腺癌亚型分类的乳腺癌发病率的种族和民族差异。
