Sohn Y Z, Katz R L
Br J Anaesth. 1979 Nov;51(11):1035-40. doi: 10.1093/bja/51.11.1035.
The effects of the polypeptide antibiotic, polymyxin B, on myocardial contractility were studied in t;e isolated rat heart muscle. Five different doses of polymyxin B were tested. There were no changes in contractility with does ranging from the clinical therapeutic value to three times greater. There was an initial increase and then depression with a dose six times greater than the therapeutic dose. There was no direct competitive interaction between polymyxin B and halothane or Ca2+. This suggests that polymyxin B does not depress the myocardium in clinical doses and does not interfere with Ca2+ influx at the myocardial cell membrane.
在离体大鼠心肌中研究了多肽抗生素多粘菌素B对心肌收缩力的影响。测试了五种不同剂量的多粘菌素B。从临床治疗剂量到三倍于临床治疗剂量的范围内，收缩力均无变化。当剂量为治疗剂量的六倍时，收缩力先增强后减弱。多粘菌素B与氟烷或Ca2+之间不存在直接的竞争性相互作用。这表明多粘菌素B在临床剂量下不会抑制心肌，也不会干扰心肌细胞膜上的Ca2+内流。
