通过钌/手性磷酸的顺序催化实现闭环复分解/异构化/Pictet-Spengler 级联反应。
Ring-closing metathesis/isomerization/Pictet-Spengler cascade via ruthenium/chiral phosphoric acid sequential catalysis.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Lett. 2012 Oct 5;14(19):5022-5. doi: 10.1021/ol302215u. Epub 2012 Sep 18.
PMID:22988945
Abstract
Chiral phosphoric acid worked together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-β-carbolines (up to 98% yield, 99% ee) through a ring-closing metathesis/isomerization/Pictet-Spengler cascade reaction via sequential catalysis.
摘要
手性磷酸与 Hoveyda-Grubbs II 催化剂协同作用，通过环 closing metathesis/isomerization/Pictet-Spengler 级联反应的顺序催化，实现了高效合成对映体富集的四氢-β-咔啉（高达 98%的产率，99%的对映体过量）。
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