通过钌亚烷基和手性磷酸的顺序催化实现烯烃异构化/不对称 Pictet-Spengler 级联反应。
An olefin isomerization/asymmetric Pictet-Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Biomol Chem. 2013 Feb 13;11(10):1602-5. doi: 10.1039/c3ob00072a.
PMID:23364474
Abstract
Chiral phosphoric acid works together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-β-carboline (up to 95% yield, 90% ee) through an olefin isomerization/Pictet-Spengler cascade reaction via sequential catalysis.
摘要
手性磷酸与 Hoveyda-Grubbs II 催化剂协同作用，通过烯烃异构化/Pictet-Spengler 级联反应的顺序催化，实现了高效合成手性富集的四氢-β-咔啉（高达 95%的产率，90%的对映选择性）。
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