Institute of Structural and Molecular Biology, Division of Life Sciences, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Trends Neurosci. 2012 Nov;35(11):691-9. doi: 10.1016/j.tins.2012.08.003. Epub 2012 Sep 16.
Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.
许多再生环境需要再生神经的存在，作为祖细胞龛的一个短暂组成部分。在这里，我们回顾了神经在脊椎动物和无脊椎动物各种结构再生中的作用。神经也被认为是哺乳动物某些干细胞龛中的持久决定因素，以及在果蝇中也是如此。我们考虑了我们目前对神经依赖性的细胞和分子机制的理解，包括与神经胶质和非神经细胞类型的关键相互作用的证据。蝾螈无神经肢体的例子表明，肢体芽与其神经支配之间的发育相互作用可以决定成年后的再生。这些现象为神经细胞提供了一个不同于基于化学和电兴奋性的观点。
