Department of Public Health, Section for Epidemiology, University of Aarhus, Bartholins Allé 2, 8000 Aarhus C, Denmark.
Reprod Toxicol. 2012 Dec;34(4):522-8. doi: 10.1016/j.reprotox.2012.08.006. Epub 2012 Aug 31.
To investigate whether sons of gardeners and building painters have increased risk of infertility in comparison with sons of bricklayers, carpenters and electricians.
Participants were men born 1965-1984 in Denmark whose fathers the year before birth had worked as gardeners, painters, bricklayers, carpenters or electricians (N=22,978). Cases of infertility were identified by Danish registers, and participants were followed-up for up to 24 years after their 20th birthday.
Sons of gardeners did not have increased risk of infertility. Hazard ratios for sons of painters fluctuated around the null in main analyses but were 1.6 (98% CI: 1.0-2.5) and 1.7 (95% CI: 0.9-3.2) in the subset of participants with smallest risk of paternal exposure misclassification.
Working as gardener or building painter was not related to increased risk of infertility among the next generation of males in main analyses. However, inherent limitations in data may have attenuated true associations.
调查与瓦工、木匠和电工的儿子相比，园丁和建筑油漆工的儿子是否有更高的不育风险。
参与者为 1965 年至 1984 年期间在丹麦出生的男性，其父亲在出生前一年从事园艺、油漆、瓦工、木匠或电工工作（N=22978）。通过丹麦登记册确定不育病例，参与者在 20 岁生日后最多随访 24 年。
园丁的儿子没有增加不育的风险。主要分析中油漆工儿子的风险比在零附近波动，但在父亲暴露错误分类风险最小的参与者亚组中，风险比为 1.6（98%CI：1.0-2.5）和 1.7（95%CI：0.9-3.2）。
在主要分析中，从事园丁或建筑油漆工工作与下一代男性不育风险增加无关。然而，数据固有的局限性可能会削弱真实关联。
