Department of Clinical Neurosciences, Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland and.
Cereb Cortex. 2013 Dec;23(12):2781-9. doi: 10.1093/cercor/bhs280. Epub 2012 Sep 17.
Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion-symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal regions.
模仿物体使用需要准确地表现动作，并选择最相关的手势。实践的突出模型，由功能神经影像学研究证实，预测左顶叶皮层在模仿中的关键作用，并提出这些区域存储工具使用的表示。相比之下，损伤数据表明左额下回区域的参与，表明运动特征选择缺陷是模仿错误的原因。我们对 150 名左脑和右脑损伤患者的构形/空间 (CS) 和以身体部位为对象 (BPO) 模仿错误进行了大规模的基于体素的损伤-症状映射分析。我们的结果证实了模仿中的左半球优势。两种类型的错误都与肿瘤和中风患者的左额下回区域损伤有关。虽然 CS 模仿错误与中风和肿瘤患者的左颞顶叶病变有关，但这些错误在中风患者中与顶叶区域的相关性较小，在肿瘤患者中与颞叶的相关性较小。BPO 错误与肿瘤和中风患者的左额下回病变有关。总的来说，我们的结果揭示了模仿各个方面的左半球内部分离，但下额叶区域的作用不明确。
