Laboratory for Neurorehabilitation Science, Medicine Section, Faculty of Science and Medicine, University of Fribourg, PER 09, Chemin du Musée 5, 1700, Fribourg, Switzerland.
Neurology Unit, Department of Internal Medicine and Specialties, Fribourg Hospital, Fribourg, Switzerland.
Brain Topogr. 2024 Nov;37(6):1033-1042. doi: 10.1007/s10548-024-01057-z. Epub 2024 Jun 10.
Inhibitory control refers to the ability to suppress cognitive or motor processes. Current neurocognitive models indicate that this function mainly involves the anterior cingulate cortex and the inferior frontal cortex. However, how the communication between these areas influence inhibitory control performance and their functional response remains unknown. We addressed this question by injecting behavioral and electrophysiological markers of inhibitory control recorded during a Go/NoGo task as the 'symptoms' in a connectome-based lesion-symptom mapping approach in a sample of 96 first unilateral stroke patients. This approach enables us to identify the white matter tracts whose disruption by the lesions causally influences brain functional activity during inhibitory control. We found a central role of left frontotemporal and frontobasal intrahemispheric connections, as well as of the connections between the left temporoparietal and right temporal areas in inhibitory control performance. We also found that connections between the left temporal and right superior parietal areas modulate the conflict-related N2 event-related potential component and between the left temporal parietal area and right temporal and occipital areas for the inhibition P3 component. Our study supports the role of a distributed bilateral network in inhibitory control and reveals that combining lesion-symptom mapping approaches with functional indices of cognitive processes could shed new light on post-stroke functional reorganization. It may further help to refine the interpretation of classical electrophysiological markers of executive control in stroke patients.
抑制控制是指抑制认知或运动过程的能力。目前的神经认知模型表明，这种功能主要涉及前扣带皮层和下额前皮层。然而，这些区域之间的通讯如何影响抑制控制性能及其功能反应仍然未知。我们通过在 96 名单侧首发卒中患者的样本中，将在 Go/NoGo 任务中记录的抑制控制的行为和电生理标志物作为“症状”，注入基于连接组的病变-症状映射方法来解决这个问题。这种方法使我们能够识别出白质束，这些白质束的破坏会导致在抑制控制期间大脑功能活动的因果影响。我们发现左额颞和额基底半球内连接以及左颞顶和右颞区之间的连接在抑制控制性能中起着核心作用。我们还发现，左颞区和右顶叶上区之间的连接调节了与冲突相关的 N2 事件相关电位成分，而左颞顶叶区与右颞区和枕叶区之间的连接则调节了抑制 P3 成分。我们的研究支持抑制控制中分布式双侧网络的作用，并揭示了将病变-症状映射方法与认知过程的功能指标相结合，可以为卒中后的功能重组提供新的认识。它可能进一步有助于更准确地解释卒中患者执行控制的经典电生理标志物。
