College of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Key Laboratory of Development and Application of Forest Chemicals of Guangxi, Nanning 530006, China.
Steroids. 2012 Nov;77(13):1398-402. doi: 10.1016/j.steroids.2012.08.006. Epub 2012 Aug 31.
The synthesis of Krempene B, which can be isolated from the marine soft coral Cladiella krempfi, is achieved in 23.9% overall yield from commercially available 3β-acetoxy-5-pregnen-20-one by 11 steps. Key transformations include the dienone-phenol rearrangement of steroids and Wittig reaction.
可从海洋软珊瑚 Cladiella krempfi 中分离得到的 Krempene B 的全合成以商业可得的 3β-乙酰氧基-5-孕甾烯-20-酮为起始原料经 11 步反应以 23.9%的总收率完成。关键转化包括甾体的二烯酮-酚重排和Wittig 反应。
