Cao Hong, Wang Xin, Huang He, Ying Shao Zhen, Gu Yong Wei, Wang Teng, Huang Cong Xin
Department of Cardiology, Renmin Hospital of Wuhan University, China.
Intern Med. 2012;51(18):2503-8. doi: 10.2169/internalmedicine.51.7714. Epub 2012 Sep 15.
Previous randomized studies have reported conflicting results on the efficacy of omega-3 fatty acids in preventing atrial fibrillation (AF) recurrences after cardioversion.
A systematic review and meta-analysis of the role of omega-3 fatty acids in the prevention of atrial fibrillation recurrences after cardioversion was conducted.
PubMed, Cochrane Library, Elsevier, Science Online database were searched up to the end of January 2012 to identify all of the studies in human subjects that reported the effects of omega-3 fatty acids on the prevention of atrial fibrillation recurrences after cardioversion.
Overall, omega-3 fatty acids had no significant effect on the prevention of AF recurrences after cardioversion (OR: 0.63,95% CI 0.35-1.13; p=0.12). The heterogeneity among the studies was significant (p=0.01, I(2)=66%). Subgroup analysis showed that by administering omega-3 fatty acids at least 4 weeks prior to cardioversion and continuing thereafter, the recurrence rate of AF is significantly low (OR: 0.39, 95% CI 0.25-0.61; p<0.0001).
In the subgroup administered omega-3 fatty acids at least 4 weeks prior to cardioversion and continued thereafter, the recurrence rate of AF was significantly low. More double-blind, randomized, placebo-controlled, multicenter studies with high quality and longer follow-up periods are needed to affirm our conclusion.
先前的随机研究报告了ω-3脂肪酸在预防心脏复律后房颤（AF）复发方面的疗效存在相互矛盾的结果。
对ω-3脂肪酸在预防心脏复律后房颤复发中的作用进行系统评价和荟萃分析。
检索截至2012年1月底的PubMed、Cochrane图书馆、爱思唯尔、科学在线数据库，以确定所有报告ω-3脂肪酸对预防心脏复律后房颤复发影响的人体研究。
总体而言，ω-3脂肪酸对预防心脏复律后房颤复发无显著影响（OR：0.63，95%CI 0.35-1.13；p=0.12）。研究间的异质性显著（p=0.01，I(2)=66%）。亚组分析表明，在心脏复律前至少4周给予ω-3脂肪酸并持续至复律后，房颤复发率显著降低（OR：0.39，95%CI 0.25-0.61；p<0.0001）。
在心脏复律前至少4周给予ω-3脂肪酸并持续至复律后的亚组中，房颤复发率显著降低。需要更多高质量、随访期更长的双盲、随机、安慰剂对照、多中心研究来证实我们的结论。
