Fujita Yukari, Tamada Daisuke, Kozawa Junji, Kobayashi Yoko, Sasaki Shugo, Kitamura Tetsuhiro, Yasuda Tetsuyuki, Maeda Norikazu, Otsuki Michio, Okita Kohei, Iwahashi Hiromi, Kaneto Hideaki, Funahashi Tohru, Imagawa Akihisa, Shimomura Iichiro
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan.
Intern Med. 2012;51(18):2581-5. doi: 10.2169/internalmedicine.51.8171. Epub 2012 Sep 15.
We herein describe a 59-year-old woman who had undergone a total gastrectomy for gastric carcinoma and suffered from postprandial hypoglycemia characterized by a loss of consciousness and spasms. She was diagnosed with reactive hypoglycemia and treated with nutrition therapy, but the frequency and severity of the hypoglycemic episodes did not decrease. She was subsequently treated successfully with miglitol, an alpha-glucosidase inhibitor (α-GI) taken twice a day; other α-GIs (acarbose and voglibose) were not effective. In conclusion, the administration of miglitol was effective for preventing reactive hypoglycemia secondary to late dumping syndrome.
我们在此描述一位59岁女性，她因胃癌接受了全胃切除术，并患有以意识丧失和痉挛为特征的餐后低血糖症。她被诊断为反应性低血糖，并接受营养治疗，但低血糖发作的频率和严重程度并未降低。随后，她使用米格列醇（一种α-葡萄糖苷酶抑制剂，每天服用两次）成功治愈；其他α-葡萄糖苷酶抑制剂（阿卡波糖和伏格列波糖）无效。总之，米格列醇给药对预防晚期倾倒综合征继发的反应性低血糖有效。
