Stephenson K, Peer S, Govender D, Fagan J J
Division of Otorhinolaryngology, University of Cape Town, South Africa.
J Laryngol Otol. 2013 Jan;127(1):96-9. doi: 10.1017/S0022215112002149. Epub 2012 Sep 19.
To report two cases of laryngeal plasmablastic lymphoma, a rare and relatively recently described form of non-Hodgkin's lymphoma. It has not previously been described in the larynx, nor associated with upper airway obstruction.
We describe the clinicopathological features of two such cases in human immunodeficiency virus positive patients, and we discuss their unusual presentations and diagnostic features.
When evaluating a laryngeal tumour, plasmablastic lymphoma and other non-Hodgkin's lymphomata should be considered as differential diagnoses, particularly in the setting of a high prevalence of human immunodeficiency virus infection. Biopsy with detailed histopathological and immunohistochemical evaluation is recommended to ensure correct diagnosis and optimal management.
