Internal Medicine E Department, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel.
Am J Med Sci. 2013 Mar;345(3):195-9. doi: 10.1097/MAJ.0b013e3182548c28.
Oxidative stress has been implicated in the pathogenesis of cardiovascular disorders, including atherosclerosis. In pharmacological doses, niacin (vitamin B3) was proven to reduce total cholesterol, triglyceride, very-low-density lipoprotein, and low-density lipoprotein levels, and to increase high-density lipoprotein (HDL) levels. The aim of this study was to evaluate the effect of niacin treatment in patients with low levels of HDL cholesterol (HDL-C; <40 mg%) on their lipid profile and oxidative stress status. Seventeen patients with hypercholesterolemia and low HDL-C and 8 healthy control subjects were enrolled in the study. The patients were treated with niacin for 12 weeks. Lipid profile, oxidative stress and C-reactive protein (CRP) levels were determined at the time of enrollment, and 2 and 12 weeks after initiation of niacin treatment. Subjects with lower HDL-C levels exhibited higher oxidative stress compared with subjects with normal HDL-C levels. Niacin treatment in hypercholesterolemic patients caused a significant increase in HDL-C and apolipoprotein A1 levels, and a decrease in triglyceride levels. Niacin also significantly reduced oxidative stress, as measured by a significant decrease in the serum content of thiobarbituric acid reactive substances, lipid peroxides and paraoxonase activity, compared with the levels before treatment. Although serum CRP levels were not affected by niacin treatment, a correlation between CRP and HDL levels was obtained when computing the results. Niacin treatment in hypercholesterolemic patients with low HDL levels caused a significant decrease in their oxidative stress status. These results indicate an additional beneficial effect of niacin beyond its ability to affect the lipid profile.
氧化应激与心血管疾病的发病机制有关，包括动脉粥样硬化。药理学剂量的烟酸（维生素 B3）已被证明可降低总胆固醇、甘油三酯、极低密度脂蛋白和低密度脂蛋白水平，并增加高密度脂蛋白（HDL）水平。本研究旨在评估烟酸治疗低水平 HDL 胆固醇（HDL-C；<40mg%）患者对其血脂谱和氧化应激状态的影响。研究纳入了 17 名高胆固醇血症和低 HDL-C 的患者和 8 名健康对照者。患者接受烟酸治疗 12 周。在入组时、开始烟酸治疗后 2 周和 12 周时测定血脂谱、氧化应激和 C 反应蛋白（CRP）水平。与 HDL-C 水平正常的受试者相比，HDL-C 水平较低的受试者表现出更高的氧化应激。烟酸治疗高胆固醇血症患者可显著增加 HDL-C 和载脂蛋白 A1 水平，并降低甘油三酯水平。烟酸还可显著降低氧化应激，血清中硫代巴比妥酸反应物质、脂质过氧化物和对氧磷酶活性的含量显著降低，与治疗前相比。尽管烟酸治疗并未影响血清 CRP 水平，但在计算结果时获得了 CRP 与 HDL 水平之间的相关性。烟酸治疗低 HDL 水平的高胆固醇血症患者可显著降低其氧化应激状态。这些结果表明烟酸除了影响血脂谱外，还有额外的有益作用。
