高密度脂蛋白与氧化
HDL and Oxidation.
机构信息
The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.
Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
出版信息
Adv Exp Med Biol. 2022;1377:63-77. doi: 10.1007/978-981-19-1592-5_5.
In this chapter, we will focus on HDLs' activity of inhibiting LDL oxidation and neutralizing some other oxidants. ApoA-I was known as the main antioxidant component in HDLs. The regulation of antioxidant capacity of HDL is mainly exhibited in regulation of apoA-I and alterations at the level of the HDL lipidome and the modifications of the proteome, especially MPO and PON1. HDL oxidation will influence the processes of inflammation and cholesterol transport, which are important processes in atherosclerosis, metabolic diseases, and many other diseases. In a word, HDL oxidation might be an effective antioxidant target in treatment of many diseases.
在这一章中，我们将重点关注 HDLs 抑制 LDL 氧化和中和其他一些氧化剂的活性。ApoA-I 被认为是 HDLs 中主要的抗氧化成分。HDL 抗氧化能力的调节主要表现在 apoA-I 的调节以及 HDL 脂质组和蛋白质组水平的改变，特别是 MPO 和 PON1 的改变。HDL 氧化会影响炎症和胆固醇转运过程，这是动脉粥样硬化、代谢性疾病和许多其他疾病的重要过程。总之，HDL 氧化可能是治疗许多疾病的有效抗氧化靶点。
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