Department of Nephrology, Shandong University Qilu Hospital, Jinan, China.
Am J Med Sci. 2013 Mar;345(3):218-21. doi: 10.1097/MAJ.0b013e318255a561.
The aim of this study was to investigate the relationship between psychiatric disorders (anxiety and depression) and quality of life (QOL) in nondialysis patients with chronic kidney disease (CKD).
QOL was evaluated in a sample of 57 nondialysis patients with CKD using the 36-item Short Form Health Survey questionnaire comprising 8 scales, including the physical component summary and mental component summary measures. Depression and anxiety were estimated using the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, respectively.
Depression and anxiety scores were negatively correlated with 7 of the 8 scales of the Short Form 36 questionnaire, and with the physical component summary and mental component summary scores, despite 38.6% patients with depression and 54.4% with anxiety, whereas QOL in the depression group, the anxiety group, and the anxiety and depression comorbid group was lower than that for those without the corresponding psychiatric disorders (P < 0.05).
This study demonstrates that depression and anxiety, commonly encountered in patients with CKD, could be a risk factor for QOL in these patients.
本研究旨在探讨非透析慢性肾脏病（CKD）患者精神障碍（焦虑和抑郁）与生活质量（QOL）之间的关系。
采用 36 项简短健康调查问卷评估 57 例非透析 CKD 患者的 QOL，该问卷包括 8 个量表，包括生理成分综合评分和心理成分综合评分。采用汉密尔顿抑郁评定量表和汉密尔顿焦虑评定量表分别评估抑郁和焦虑。
抑郁和焦虑评分与 36 项简短健康调查问卷的 8 个量表中的 7 个量表呈负相关，与生理成分综合评分和心理成分综合评分呈负相关，尽管 38.6%的患者有抑郁，54.4%的患者有焦虑，而抑郁组、焦虑组和焦虑合并抑郁组的 QOL 低于无相应精神障碍的患者（P < 0.05）。
本研究表明，CKD 患者常见的抑郁和焦虑可能是这些患者 QOL 的一个危险因素。
