College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Am J Med Sci. 2013 Mar;345(3):234-7. doi: 10.1097/MAJ.0b013e318265b146.
The aim of this study was to review the orofacial manifestations in patients with sickle cell disease (SCD).
Indexed databases were explored using various combinations of the following keywords: "sickle cell anemia," "sickle cell disease," "oral health status" and "dental inflammation."
Hypoxia has been associated with osteomyelitis of the jaws, particularly the mandible in patients with SCD. Bone marrow hyperplasia in these patients causes depression of nasal bridge, midfacial overgrowth and malocclusion. Mental nerve neuropathy due to osteomyelitis of the mandible causes numbness in the lower lip and chin. A diminished blood supply to teeth causes necrosis of the dental pulp in patients with SCD. Dental caries is a common manifestation in patients with SCD, particularly in those with underprivileged living standards. The association between SCD and periodontal inflammatory conditions remains unclear.
Oral health problems in patients with SCD are rare and occur mainly as a result of the poor oral hygiene maintenance.
本研究旨在回顾镰状细胞病（SCD）患者的口腔表现。
使用以下关键词的各种组合来探索索引数据库：“镰状细胞性贫血”、“镰状细胞病”、“口腔健康状况”和“牙科炎症”。
缺氧与颌骨骨髓炎有关，特别是 SCD 患者的下颌骨。这些患者的骨髓增生导致鼻梁凹陷、面中部过度生长和咬合不正。下颌骨骨髓炎导致的面神经神经病导致下唇和下巴麻木。SCD 患者牙齿的血液供应减少会导致牙髓坏死。牙本质龋是 SCD 患者的常见表现，尤其是生活水平较差的患者。SCD 与牙周炎症状况之间的关联尚不清楚。
SCD 患者的口腔健康问题很少见，主要是由于口腔卫生维护不佳所致。
