Kakkar Mayank, Holderle Kristen, Sheth Megha, Arany Szilvia, Schiff Leslie, Planerova Adela
Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Department of Psychiatry and Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
Anemia. 2021 Oct 22;2021:5556708. doi: 10.1155/2021/5556708. eCollection 2021.
Sickle cell disease (SCD) is an upcoming global health problem with rapid progress in therapy especially since 2017. However, systematic reviews found no clinical trials on the dental treatment of sickle cell disease (SCD). This article aims to outline the oral features of the sickle disease and discuss oral management strategies that can serve as guidelines for dental professionals. . A comprehensive literature review was conducted using PubMed, Google Scholar, and Web of Science. The search strategies were developed to cover publications from January 2010 to March 2020. With the help of keywords, multiple abstracts were identified. These abstracts were further reviewed, which included the information about the SCD manifestation, particularly about the oral health features. Based on all these articles and clinical experience, a narrative review was constructed, which summarizes all the aspects of the oral manifestation in people with SCD.
The results of this study demonstrate that there is distinct evidence available, indicating the developmental enamel defect leading to hypoplasia and increasing susceptibility to dental caries. Another important result of this review found that people with SCD have a vaso-occlusive crisis in the microcirculation in the dental pulp leading to symptomatic and asymptomatic pulpal necrosis without any signs of odontogenic pathology in an apparently healthy tooth. The study also found that early detection, intervention, and prevention are crucial for improving oral health care, and involving a multidisciplinary approach plays an important role in managing people with SCD.
Patients with sickle cell disease have chronic overall health problems. The hematological disorder becomes their main concern and impaired oral health becomes secondary, increasing the risk for dental caries at the most. This paper broadly describes the oral manifestations of SCD, additionally; this paper also provides recommendations for better dental management of patients with SCD. Patients with SCD are often misjudged and, due to lack of knowledge and guidelines, dental providers are not able to provide adequate care. This paper attempts to highlight the essential measures to provide better dental care.
镰状细胞病（SCD）是一个日益凸显的全球健康问题，特别是自2017年以来，其治疗取得了快速进展。然而，系统评价发现尚无关于镰状细胞病（SCD）牙科治疗的临床试验。本文旨在概述镰状细胞病的口腔特征，并讨论可作为牙科专业人员指导方针的口腔管理策略。使用PubMed、谷歌学术和科学网进行了全面的文献综述。制定的检索策略涵盖了2010年1月至2020年3月的出版物。借助关键词，识别出多篇摘要。对这些摘要进行了进一步审查，其中包括有关SCD表现的信息，特别是有关口腔健康特征的信息。基于所有这些文章和临床经验，构建了一篇叙述性综述，总结了SCD患者口腔表现的各个方面。
本研究结果表明，有明确证据表明存在发育性釉质缺陷，导致釉质发育不全，并增加患龋齿的易感性。该综述的另一个重要结果发现，SCD患者牙髓微循环中存在血管阻塞性危机，导致有症状和无症状的牙髓坏死，而在一颗看似健康的牙齿中没有任何牙源性病变的迹象。该研究还发现，早期检测、干预和预防对于改善口腔保健至关重要，采用多学科方法在管理SCD患者中发挥着重要作用。
镰状细胞病患者存在慢性整体健康问题。血液系统疾病成为他们的主要关注点，而口腔健康受损则成为次要问题，最多只会增加患龋齿的风险。本文广泛描述了SCD的口腔表现；此外，本文还为更好地管理SCD患者的牙科治疗提供了建议。SCD患者常常被误诊，并且由于缺乏知识和指导方针，牙科医疗人员无法提供充分的护理。本文试图强调提供更好牙科护理的基本措施。
