Departamento de Biociências, Vila Mathias, Santos - SP, Brazil.
Cancer Genomics Proteomics. 2012 Sep-Oct;9(5):329-35.
Oral cancer is a common neoplasm worldwide. Its incidence and mortality have also increased over the past decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. Metastasis of oral cancer is a complex process involving detachment of cells from tumor tissue, regulation of cell motility and invasion, proliferation and evasion through the lymphatic system or blood vessels. In this review, we will focus on the current knowledge in metastasis from oral cancer regarding facts, such as incidence; stage, histopathology and grade of primary tumor; clinical manifestations; diagnosis; and treatment. Certainly, such information will contribute to the understanding of oral cancer pathogenesis.
口腔癌是一种常见的全球范围内的恶性肿瘤。在过去几十年中，其发病率和死亡率也有所上升。尽管采用了复杂的手术和放射治疗方法，但它的预后仍然很差，生存率也很低。口腔癌的转移是一个复杂的过程，涉及到细胞从肿瘤组织上的脱离、细胞运动和侵袭的调节、通过淋巴系统或血管的增殖和逃逸。在这篇综述中，我们将重点介绍目前关于口腔癌转移的知识，包括发病率、原发肿瘤的分期、组织病理学和分级、临床表现、诊断和治疗等方面的事实。当然，这些信息将有助于理解口腔癌的发病机制。
