Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
Clin Pharmacol Ther. 2012 Nov;92(5):613-21. doi: 10.1038/clpt.2012.102. Epub 2012 Sep 19.
Transforming growth factor-β (TGF-β) influences the development of myocardiopathy in Chagas disease through regulation of (i) parasite invasion of heart cells, (ii) an intracellular parasite cycle, (iii) inflammation and immune response, (iv) heart fibrosis and remodeling, and (v) gap junction modulation and heart conduction. In this review, we discuss the rationale for developing TGF-β signaling-interfering therapies as adjuvant approaches for the management of the cardiac alterations of Chagas disease-affected patients.
转化生长因子-β（TGF-β）通过调节以下几个方面影响恰加斯病中心肌病的发展：（i）寄生虫对心脏细胞的侵袭，（ii）细胞内寄生虫周期，（iii）炎症和免疫反应，（iv）心脏纤维化和重塑，以及（v）缝隙连接调节和心脏传导。在这篇综述中，我们讨论了开发 TGF-β信号转导干扰疗法作为辅助治疗恰加斯病患者心脏改变的合理性。
