Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Clin Infect Dis. 2013 Jan;56(1):40-50. doi: 10.1093/cid/cis815. Epub 2012 Sep 18.
The Chronic Hepatitis Cohort Study (CHeCS), a dynamic prospective, longitudinal, observational cohort study, was created to assess the clinical impact of chronic viral hepatitis in the United States. This report describes the cohort selection process, baseline demographics, and insurance, biopsy, hospitalization, and mortality rates.
Electronic health records of >1.6 million adult patients seen from January 2006 through December 2010 at 4 integrated healthcare systems in Detroit, Michigan; Danville, Pennsylvania; Portland, Oregon; and Honolulu, Hawaii were collected and analyzed.
Of 2202 patients with chronic hepatitis B virus (HBV) infection, 50% were aged 44-63 years, 57% male, 58% Asian/Pacific Islander, and 13% black; and 5.1% had Medicaid, 16.5% Medicare, and 76.3% private insurance. During 2001-2010, 22.3% had a liver biopsy and 37.9% were hospitalized. For the 8810 patients with chronic hepatitis C virus (HCV) infection, 75% were aged 44-63 years, 60% male, 23% black; and 12% had Medicaid, 23% Medicare, and 62% private insurance. During 2001-2010, 38.4% had a liver biopsy and 44.3% were hospitalized. Among persons in care, 9% of persons with HBV and 14% of persons with HCV infection, mainly those born during 1945-1964, died during the 2006-2010 five-year period.
Baseline demographic, hospitalization, and mortality data from CHeCS highlight the substantial US health burden from chronic viral hepatitis, particularly among persons born during 1945-1964.
慢性丙型肝炎队列研究（CHeCS）是一项动态的前瞻性、纵向观察队列研究，旨在评估美国慢性病毒性肝炎的临床影响。本报告描述了队列选择过程、基线人口统计学特征以及保险、活检、住院和死亡率。
从密歇根州底特律、宾夕法尼亚州丹维尔、俄勒冈州波特兰和夏威夷檀香山的 4 个综合医疗保健系统收集并分析了 2006 年 1 月至 2010 年 12 月期间就诊的 160 多万名成年患者的电子健康记录。
在 2202 名慢性乙型肝炎病毒（HBV）感染者中，50%的年龄在 44-63 岁之间，57%为男性，58%为亚裔/太平洋岛民，13%为黑人；5.1%有医疗补助，16.5%有医疗保险，76.3%有私人保险。在 2001-2010 年期间，22.3%的患者进行了肝活检，37.9%的患者住院治疗。在 8810 名慢性丙型肝炎病毒（HCV）感染者中，75%的年龄在 44-63 岁之间，60%为男性，23%为黑人；12%有医疗补助，23%有医疗保险，62%有私人保险。在 2001-2010 年期间，38.4%的患者进行了肝活检，44.3%的患者住院治疗。在接受治疗的人群中，HBV 感染者中有 9%，HCV 感染者中有 14%（主要是 1945-1964 年出生的人）在 2006-2010 年五年期间死亡。
CHeCS 的基线人口统计学、住院和死亡率数据突出了美国慢性病毒性肝炎的巨大健康负担，特别是在 1945-1964 年出生的人群中。
