通过相互依存的负调控途径层来抑制炎症信号。
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways.
机构信息
Department of Infectious Diseases and Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
出版信息
Nat Immunol. 2012 Oct;13(10):916-24. doi: 10.1038/ni.2391. Epub 2012 Sep 18.
Abstract
Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of excessive inflammation is cell and tissue damage, an underlying cause of many acute and chronic diseases. Coincident with activation of TLR signaling, a plethora of anti-inflammatory pathways and mechanisms begin to modulate inflammation until tissue repair is complete. Whereas most studies have focused on the signaling components immediately downstream of the TLRs, this Review summarizes the different levels of anti-inflammatory pathways that have evolved to abate TLR signaling and how they are integrated to prevent cell and tissue destruction.
摘要
Toll 样受体（TLR）信号及其相关途径的激活可被微生物产物驱动，从而引发炎症反应、宿主防御途径和适应性免疫。过度炎症的代价是细胞和组织损伤，这是许多急性和慢性疾病的根本原因。与 TLR 信号的激活同时发生的是，大量的抗炎途径和机制开始调节炎症，直到组织修复完成。虽然大多数研究都集中在 TLR 下游的信号成分上，但本综述总结了进化而来的不同水平的抗炎途径，以减轻 TLR 信号，并探讨它们是如何整合以防止细胞和组织破坏的。
相似文献
1
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways.通过相互依存的负调控途径层来抑制炎症信号。
Nat Immunol. 2012 Oct;13(10):916-24. doi: 10.1038/ni.2391. Epub 2012 Sep 18.
2
The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases.Toll 样受体信号通路在无菌性炎症性疾病中的重要作用。
Int Immunopharmacol. 2011 Oct;11(10):1422-32. doi: 10.1016/j.intimp.2011.04.026. Epub 2011 May 18.
3
Therapeutic targeting of toll-like receptors in gastrointestinal inflammation.胃肠道炎症中Toll样受体的治疗靶向作用
Curr Pharm Des. 2006;12(32):4215-28. doi: 10.2174/138161206778743448.
4
Dissecting negative regulation of Toll-like receptor signaling.解析 Toll 样受体信号转导的负调控。
Trends Immunol. 2012 Sep;33(9):449-58. doi: 10.1016/j.it.2012.05.002. Epub 2012 Jun 20.
5
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders.炎症性疾病中的Toll样受体（TLRs）和核苷酸结合寡聚化结构域样受体（NLRs）
Semin Immunol. 2009 Aug;21(4):242-53. doi: 10.1016/j.smim.2009.06.005.
6
Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity.顺铂通过大量产生白细胞介素-10对Toll样受体激动剂作出反应，诱导产生耐受性树突状细胞，从而促进偏向于辅助性T细胞2型和1型调节性T细胞的免疫反应。
Oncotarget. 2016 Jun 7;7(23):33765-82. doi: 10.18632/oncotarget.9260.
7
Nerve growth factor downregulates inflammatory response in human monocytes through TrkA.神经生长因子通过 TrkA 下调人单核细胞的炎症反应。
J Immunol. 2014 Apr 1;192(7):3345-54. doi: 10.4049/jimmunol.1300825. Epub 2014 Feb 28.
8
STAT1 plays a role in TLR signal transduction and inflammatory responses.信号转导及转录激活因子1（STAT1）在Toll样受体（TLR）信号转导和炎症反应中发挥作用。
Immunol Cell Biol. 2014 Oct;92(9):761-9. doi: 10.1038/icb.2014.51. Epub 2014 Jul 15.
9
Gene-specific control of the TLR-induced inflammatory response.Toll样受体（TLR）诱导的炎症反应的基因特异性调控
Clin Immunol. 2009 Jan;130(1):7-15. doi: 10.1016/j.clim.2008.08.015. Epub 2008 Oct 28.
10
Induction of cytokines and chemokines by Toll-like receptor signaling: strategies for control of inflammation.Toll样受体信号传导诱导细胞因子和趋化因子：控制炎症的策略
Crit Rev Immunol. 2010;30(1):53-67. doi: 10.1615/critrevimmunol.v30.i1.40.
引用本文的文献
1
PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses.PTEN调节尿路感染易感性并塑造尿路上皮抗菌防御。
Life Sci Alliance. 2025 Jul 23;8(10). doi: 10.26508/lsa.202503292. Print 2025 Oct.
2
IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms.白细胞介素-10通过表观遗传机制靶向干扰素调节因子转录因子，以抑制干扰素和炎症反应基因。
Nat Immunol. 2025 May;26(5):748-759. doi: 10.1038/s41590-025-02137-3. Epub 2025 Apr 22.
3
Targeting mTOR in myeloid cells prevents infection-associated inflammation.靶向髓系细胞中的mTOR可预防感染相关炎症。
iScience. 2025 Mar 4;28(4):112163. doi: 10.1016/j.isci.2025.112163. eCollection 2025 Apr 18.
4
Clinical applications of oligonucleotides for cancer therapy.寡核苷酸在癌症治疗中的临床应用。
Mol Ther. 2025 Jun 4;33(6):2705-2718. doi: 10.1016/j.ymthe.2025.02.045. Epub 2025 Mar 5.
5
Betaine enhances hepatic antioxidant activity and thymus-associated immunity in lipopolysaccharide-challenged goslings.甜菜碱可增强脂多糖刺激的雏鹅的肝脏抗氧化活性和胸腺相关免疫力。
BMC Vet Res. 2025 Feb 19;21(1):77. doi: 10.1186/s12917-025-04527-z.
6
Macrophages as Potential Therapeutic Targets in Acute Myeloid Leukemia.巨噬细胞作为急性髓系白血病潜在的治疗靶点
Biomedicines. 2024 Oct 11;12(10):2306. doi: 10.3390/biomedicines12102306.
7
A Protective Role of Canonical Wnt/-Catenin Pathway in Pathogenic Bacteria-Induced Inflammatory Responses.经典 Wnt/-连环蛋白通路在致病菌诱导的炎症反应中的保护作用。
Mediators Inflamm. 2024 Feb 27;2024:8869510. doi: 10.1155/2024/8869510. eCollection 2024.
8
Macro- and micro-scale culture environment differentially regulate the effects of crowding on macrophage function.宏观和微观培养环境对拥挤对巨噬细胞功能的影响有不同的调节作用。
Biotechnol Bioeng. 2024 Jan;121(1):306-316. doi: 10.1002/bit.28554. Epub 2023 Oct 4.
9
Single-cell analysis reveals TLR-induced macrophage heterogeneity and quorum sensing dictate population wide anti-inflammatory feedback in response to LPS.单细胞分析揭示 TLR 诱导的巨噬细胞异质性和群体感应决定了 LPS 反应中的广泛抗炎反馈。
Front Immunol. 2023 Feb 24;14:1135223. doi: 10.3389/fimmu.2023.1135223. eCollection 2023.
10
Regulation of macrophage IFNγ-stimulated gene expression by the transcriptional coregulator CITED1.转录共激活因子 CITED1 调控巨噬细胞 IFNγ 刺激基因的表达。
J Cell Sci. 2023 Jan 1;136(1). doi: 10.1242/jcs.260529. Epub 2022 Jan 3.
本文引用的文献
1
Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.转录共激活因子 GRIP1 在糖皮质激素抗炎作用中的作用。
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11776-81. doi: 10.1073/pnas.1206059109. Epub 2012 Jul 2.
2
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.TLR4 调控的原代人源和鼠源巨噬细胞基因表达的保守性与差异性。
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E944-53. doi: 10.1073/pnas.1110156109. Epub 2012 Mar 26.
3
MARCKS as a negative regulator of lipopolysaccharide signaling.MARCKS 作为脂多糖信号的负调控因子。
J Immunol. 2012 Apr 15;188(8):3893-902. doi: 10.4049/jimmunol.1003605. Epub 2012 Mar 16.
4
Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide.猪骨髓来源的巨噬细胞在对细菌脂多糖的反应中类似于人巨噬细胞。
J Immunol. 2012 Apr 1;188(7):3382-94. doi: 10.4049/jimmunol.1102649. Epub 2012 Mar 5.
5
Beyond pattern recognition: five immune checkpoints for scaling the microbial threat.超越模式识别：五个免疫检查点来应对微生物威胁。
Nat Rev Immunol. 2012 Feb 24;12(3):215-25. doi: 10.1038/nri3167.
6
Shigella: a model of virulence regulation in vivo.志贺氏菌：活体中毒力调节的典范。
Gut Microbes. 2012 Mar-Apr;3(2):104-20. doi: 10.4161/gmic.19325. Epub 2012 Mar 1.
7
Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K.患者缺乏 PI3K 的 p85α 亚基，表现为丙种球蛋白血症和 B 细胞谱系缺失。
J Exp Med. 2012 Mar 12;209(3):463-70. doi: 10.1084/jem.20112533. Epub 2012 Feb 20.
8
Autophagy in regulation of Toll-like receptor signaling.自噬在 Toll 样受体信号转导中的调控作用。
Cell Signal. 2012 Jun;24(6):1150-62. doi: 10.1016/j.cellsig.2012.01.020. Epub 2012 Feb 4.
9
Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages.体内 STAT3 结合的全基因组分析预测了巨噬细胞抗炎反应的效应物。
Blood. 2012 Mar 29;119(13):e110-9. doi: 10.1182/blood-2011-09-381483. Epub 2012 Feb 9.
10
Accessory molecules for Toll-like receptors and their function. toll 样受体的辅助分子及其功能。
Nat Rev Immunol. 2012 Feb 3;12(3):168-79. doi: 10.1038/nri3151.
Zotero 插件