白三烯C4在人体内的消除与代谢。

Leukotriene C4 elimination and metabolism in man.

作者信息

Maltby N H, Taylor G W, Ritter J M, Moore K, Fuller R W, Dollery C T

机构信息

Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, England.

出版信息

J Allergy Clin Immunol. 1990 Jan;85(1 Pt 1):3-9. doi: 10.1016/0091-6749(90)90214-o.

DOI:10.1016/0091-6749(90)90214-o

PMID:2299103

Abstract

Three doses of radiolabeled leukotriene C4 (0.2 to 15 muCi) were infused into three subjects to investigate its metabolism and routes of elimination during 4 days. Between 12% and 20% of the infused dose was recovered in the urine within 24 hours, of which a substantial and relatively constant proportion (4.1% to 6.3% total dose) appeared as leukotriene E4 (LTE4), mainly in the first 4 hours. Polar omega-oxidation products, N-acetyl LTE4, and tritiated water were also present. Fecal elimination accounted for a further 30% to 40% of the infused dose. In the absence of altered metabolism or biliary excretion, urinary LTE4 may be a useful measure of whole body production of the cysteinyl leukotrienes.

摘要

向三名受试者输注三剂放射性标记的白三烯C4（0.2至15微居里），以研究其在4天内的代谢和消除途径。在24小时内，尿液中回收了注入剂量的12%至20%，其中相当大且相对恒定比例（占总剂量的4.1%至6.3%）以白三烯E4（LTE4）的形式出现，主要在最初4小时内。还存在极性ω-氧化产物、N-乙酰基LTE4和氚水。粪便排泄量占注入剂量的另外30%至40%。在代谢或胆汁排泄未改变的情况下，尿LTE4可能是全身半胱氨酰白三烯生成的有用指标。