Alguacil Ramos Ana María, Lluch Rodrigo José Antonio, Portero Alonso Antonio, Martín Ivorra Rosa, Pastor Villalba Eliseo
Conselleria de Sanitat, Conselleria de Sanitat (Valencia), Valencia, España.
Rev Esp Salud Publica. 2012 May-Jun;86(3):241-51. doi: 10.1590/S1135-57272012000300004.
The loss of confidence in the safety of vaccines derived from alarm conditions, as in the case of the flu pandemic may affect both vaccination coverage and the sensitivity to the reporting of suspected adverse reactions associated vaccines (SRAAV). The aim of the study is to describe the adverse effects reported to the vaccine against pandemic influenza in the 2009-2010 season and against seasonal influenza in 2009-2010 and 2010-2011 seasons, by type of vaccine, risk groups and by age group in the Valencian Community (CV).
A retrospective descriptive study has been made of the individuals presenting suspected adverse reactions to the influenza vaccine reported through the Vaccine Information System during the seasons 2009-2010 and 2010-2011 in the Valencian Community. 95% confidence intervals were calculated.
During the period 2009-2010 the reporting rate of suspected reactions for seasonal influenza vaccine was 0.020 per thousand doses administered, for the pandemic vaccine 0.95. The reporting rate for seasonal influenza vaccine in the period 2010-2011 was 0.04 per thousand.
There was an increase in the number of reported suspected adverse reactions to the pandemic vaccines compared with the rest of influenza vaccines, during the seasons. The highest suspected adverse reaction reporting rate was for the group of health professionals partner for both vaccines against seasonal and pandemic influenza.
对流感大流行等警报情况下疫苗安全性信心的丧失，可能会影响疫苗接种覆盖率以及与疫苗相关的疑似不良反应报告（SRAAV）的敏感度。本研究的目的是按疫苗类型、风险群体和巴伦西亚自治区（CV）的年龄组，描述2009 - 2010季节针对大流行性流感疫苗以及2009 - 2010年和2010 - 2011年季节针对季节性流感疫苗报告的不良反应。
对2009 - 2010年和2010 - 2011年季节期间通过疫苗信息系统报告的对流感疫苗有疑似不良反应的个体进行回顾性描述性研究。计算了95%的置信区间。
在2009 - 2010年期间，季节性流感疫苗的疑似反应报告率为每千剂接种量0.020，大流行性疫苗为0.95。2010 - 2011年期间季节性流感疫苗的报告率为每千剂0.04。
在这些季节中，与其他流感疫苗相比，大流行性疫苗报告的疑似不良反应数量有所增加。针对季节性和大流行性流感疫苗，卫生专业人员群体的疑似不良反应报告率最高。
