• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model.胎儿肺动脉血管阻抗在近足月的非人类灵长类动物模型中反映胎儿的氧合变化。
Reprod Sci. 2013 Jan;20(1):33-8. doi: 10.1177/1933719112459224. Epub 2012 Sep 18.
2
Reactivity of the human fetal pulmonary circulation to maternal hyperoxygenation increases during the second half of pregnancy: a randomized study.孕期后半期胎儿肺循环对母体高氧的反应性增加：一项随机研究。
Circulation. 1998 Jan 27;97(3):257-62. doi: 10.1161/01.cir.97.3.257.
3
Prenatal prediction of neonatal haemodynamic adaptation after maternal hyperoxygenation.母体高氧后新生儿血流动力学适应的产前预测
BMC Pregnancy Childbirth. 2020 Nov 19;20(1):706. doi: 10.1186/s12884-020-03403-y.
4
Ductus venosus velocimetry in acute fetal acidemia and impending fetal death in a sheep model of increased placental vascular resistance.静脉导管血流速度在增加胎盘血管阻力的绵羊模型中急性胎儿酸中毒和即将发生的胎儿死亡中的应用。
Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1229-34. doi: 10.1152/ajpheart.01299.2008. Epub 2010 Jan 22.
5
Effects of maternal hyperoxia with and without normocapnia in uteroplacental and fetal Doppler studies.在子宫胎盘和胎儿多普勒研究中，伴有和不伴有正常碳酸血症的母体高氧血症的影响。
Ultrasound Obstet Gynecol. 2005 Oct;26(5):495-9. doi: 10.1002/uog.1995.
6
Fetal branch pulmonary arterial vascular impedance during the second half of pregnancy.妊娠后半期胎儿分支肺动脉血管阻抗
Am J Obstet Gynecol. 1996 May;174(5):1441-9. doi: 10.1016/s0002-9378(96)70586-0.
7
Parameters of fetal pulmonary vascular health: baseline trends and response to maternal hyperoxia in the second and third trimesters.胎儿肺血管健康参数：中晚期母胎高氧环境下的基线趋势及反应。
Ultrasound Obstet Gynecol. 2017 Nov;50(5):618-623. doi: 10.1002/uog.17383.
8
Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance.胎儿心室舒张充盈特征在灵长类动物模型中的表现：胎儿心率和肺血管阻抗的作用。
Reprod Sci. 2010 Aug;17(8):760-6. doi: 10.1177/1933719110370490.
9
Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model.慢性近足月绵羊模型中胎儿氧合及心血管血流动力学的多普勒超声检查
Am J Obstet Gynecol. 2006 Feb;194(2):542-50. doi: 10.1016/j.ajog.2005.08.028.
10
Human fetal pulmonary artery velocimetry: repeatability and normal values with emphasis on middle and distal pulmonary vessels.
Ultrasound Obstet Gynecol. 2000 Jun;15(6):479-86. doi: 10.1046/j.1469-0705.2000.00134.x.

引用本文的文献

1
Maternal azithromycin therapy for Ureaplasma parvum intraamniotic infection improves fetal hemodynamics in a nonhuman primate model.阿奇霉素治疗解脲脲原体羊膜腔感染可改善非人灵长类动物模型的胎儿血液动力学。
Am J Obstet Gynecol. 2020 Oct;223(4):578.e1-578.e11. doi: 10.1016/j.ajog.2020.04.015. Epub 2020 Apr 25.
2
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.怀孕恒河猴感染寨卡病毒会导致胎盘功能障碍和免疫病理学变化。
Nat Commun. 2018 Jan 17;9(1):263. doi: 10.1038/s41467-017-02499-9.
3
Brain sparing in fetal mice: BOLD MRI and Doppler ultrasound show blood redistribution during hypoxia.胎儿鼠的脑保护：BOLD MRI 和多普勒超声显示缺氧时血液重新分布。
J Cereb Blood Flow Metab. 2014 Jun;34(6):1082-8. doi: 10.1038/jcbfm.2014.62. Epub 2014 Apr 9.

本文引用的文献

1
Regulation of the pulmonary circulation in the fetus and newborn.胎儿和新生儿肺循环的调节。
Physiol Rev. 2010 Oct;90(4):1291-335. doi: 10.1152/physrev.00032.2009.
2
Antenatal testing-a reevaluation: executive summary of a Eunice Kennedy Shriver National Institute of Child Health and Human Development workshop.产前检查——重新评估：尤妮斯·肯尼迪·施莱佛国家儿童健康与人类发展研究所研讨会执行摘要
Obstet Gynecol. 2009 Mar;113(3):687-701. doi: 10.1097/AOG.0b013e318197bd8a.
3
Amniotic fluid S100B protein and erythropoietin in pregnancies at risk for fetal hypoxia.胎儿缺氧风险妊娠中的羊水S100B蛋白和促红细胞生成素
Eur J Obstet Gynecol Reprod Biol. 2009 Feb;142(2):115-8. doi: 10.1016/j.ejogrb.2008.10.008. Epub 2008 Nov 29.
4
Sources of amniotic fluid erythropoietin during normoxia and hypoxia in fetal sheep.正常氧合和低氧条件下胎羊羊水促红细胞生成素的来源
Am J Obstet Gynecol. 2006 Jul;195(1):246-54. doi: 10.1016/j.ajog.2005.12.008. Epub 2006 Apr 21.
5
Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model.慢性近足月绵羊模型中胎儿氧合及心血管血流动力学的多普勒超声检查
Am J Obstet Gynecol. 2006 Feb;194(2):542-50. doi: 10.1016/j.ajog.2005.08.028.
6
Physiology of the fetal circulation.胎儿循环生理学。
Semin Fetal Neonatal Med. 2005 Dec;10(6):493-503. doi: 10.1016/j.siny.2005.08.007. Epub 2005 Oct 19.
7
Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases.高血压与心血管疾病中动脉僵硬度和脉压的当前观点
Circulation. 2003 Jun 10;107(22):2864-9. doi: 10.1161/01.CIR.0000069826.36125.B4.
8
Effect of NO, phenylephrine, and hypoxemia on ductus venosus diameter in fetal sheep.一氧化氮、去氧肾上腺素和低氧血症对胎羊静脉导管直径的影响。
Am J Physiol Heart Circ Physiol. 2000 Sep;279(3):H1166-71. doi: 10.1152/ajpheart.2000.279.3.H1166.
9
Vascular potassium channels mediate oxygen-induced pulmonary vasodilation in fetal lambs.血管钾通道介导胎羊氧诱导的肺血管舒张。
Biol Neonate. 2000;77(1):58-68. doi: 10.1159/000014196.
10
Doppler ultrasound evaluation of ductus venosus blood flow during acute hypoxemia in fetal lambs.胎儿羔羊急性低氧血症期间静脉导管血流的多普勒超声评估。
Ultrasound Obstet Gynecol. 1998 Jun;11(6):426-31. doi: 10.1046/j.1469-0705.1998.11060426.x.

胎儿肺动脉血管阻抗在近足月的非人类灵长类动物模型中反映胎儿的氧合变化。

Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model.

机构信息

Department of Obstetrics & Gynecology, Maternal Fetal Medicine Division, Oregon Health & Science University, Portland, OR, USA.

出版信息

Reprod Sci. 2013 Jan;20(1):33-8. doi: 10.1177/1933719112459224. Epub 2012 Sep 18.

DOI:10.1177/1933719112459224
PMID:22991382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3676239/
Abstract

OBJECTIVE

We tested the hypothesis that fetal pulmonary arterial circulation reacts to changes in fetal oxygenation status at near-term gestation.

STUDY DESIGN

A total of 20 rhesus macaques underwent fetal Doppler ultrasonography at near-term gestation. Right pulmonary artery (RPA), umbilical artery (UA), ductus arteriosus (DA), and ductus venosus (DV) blood velocity waveforms were obtained, and pulsatility index (PI) values were calculated. Fetal right and left ventricular cardiac outputs were determined. Ultrasonographic data were collected during 3 maternal oxygenation states: room air (baseline), hyperoxemia, and hypoxemia.

RESULTS

Fetal RPA PI values increased (P < .05) during maternal hypoxemia and decreased (P < .05) during maternal hyperoxemia, compared with baseline. Maternal hyperoxemia increased (P < .05) DA PI values from baseline. Fetal cardiac outputs, UA, and DV PI values were not affected.

CONCLUSIONS

Our results demonstrate that at near-term gestation, fetal pulmonary arterial circulation is a dynamic vascular bed that reflects acute and short-term changes in fetal oxygenation.

摘要

目的

我们检验了这样一个假设，即在接近足月妊娠时，胎儿肺循环对胎儿氧合状态的变化会产生反应。

研究设计

总共 20 只恒河猴在接近足月妊娠时接受胎儿多普勒超声检查。获取右肺动脉（RPA）、脐动脉（UA）、动脉导管（DA）和静脉导管（DV）的血流速度波形，并计算搏动指数（PI）值。确定胎儿左右心室的心输出量。超声数据在 3 种母体氧合状态下收集：空气（基线）、高氧血症和低氧血症。

结果

与基线相比，胎儿 RPA 的 PI 值在母体低氧血症时增加（P <.05），在母体高氧血症时降低（P <.05）。母体高氧血症使 DA 的 PI 值从基线升高（P <.05）。胎儿心输出量、UA 和 DV 的 PI 值不受影响。

结论

我们的结果表明，在接近足月妊娠时，胎儿肺循环是一个动态的血管床，它反映了胎儿氧合的急性和短期变化。