Department of Psychology, Boston University, Boston, MA, USA.
Cogn Behav Ther. 2012;41(4):335-44. doi: 10.1080/16506073.2012.711770. Epub 2012 Sep 20.
Research on D-cycloserine (DCS) has demonstrated a significant effect on symptom reduction in human studies that utilized conventional exposure-based approaches. Recent studies have offered promising results for targeting fears through subliminal paradigms. In this double-blind, randomized placebo-controlled study, 45 spider fearful individuals received DCS or placebo pills prior to completing a subliminal cue exposure task to images of spiders. Participants completed self-report questionnaires and a behavioral approach task to a live caged tarantula. After repeated exposure to subliminal spider cues, participants in the DCS group reported a greater reduction in disgust than individuals in the placebo group. No difference was observed in fear ratings. These findings suggest that DCS augments the reduction in disgust in spider fearful subjects after subliminal exposure to spider cues.
关于 D-环丝氨酸（DCS）的研究表明，在利用传统暴露为基础的方法进行的人类研究中，它对减轻症状有显著效果。最近的研究为通过潜意识范式针对恐惧提供了有希望的结果。在这项双盲、随机安慰剂对照研究中，45 名蜘蛛恐惧个体在完成潜意识线索暴露任务之前接受 DCS 或安慰剂药丸，以观察蜘蛛的图像。参与者完成了自我报告问卷和对活笼养狼蛛的行为趋近任务。在反复暴露于潜意识蜘蛛线索后，DCS 组的参与者报告说，与安慰剂组的个体相比，他们对厌恶的反应降低了更多。在恐惧评分方面没有观察到差异。这些发现表明，DCS 增强了在潜意识暴露于蜘蛛线索后，对蜘蛛恐惧个体厌恶的减少。
