Pulmonary, Allergy and Critical Care Division, Translational Research Laboratories, 125 South 31st Street, Philadelphia, PA 19104-3403, USA.
Respir Res. 2012 Sep 19;13(1):80. doi: 10.1186/1465-9921-13-80.
The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD). The airways of patients suffering from COPD are infiltrated by various immune and inflammatory cells including macrophages, neutrophils, T lymphocytes, and dendritic cells. While the role of macrophages, neutrophils and T lymphocytes is well characterized, the contribution of dendritic cells to COPD pathogenesis is still the subject of emerging research. A paper by Botelho and colleagues in the current issue of Respiratory Research investigates the importance of dendritic cell recruitment in cigarette-smoke induced acute and chronic inflammation in mice. Dendritic cells of the healthy lung parenchyma and airways perform an important sentinel function and regulate immune homeostasis. During inflammatory responses the function and migration pattern of these cells is dramatically altered but the underlying mechanisms are incompletely understood. Botelho and colleagues demonstrate here the importance of IL-1R1/IL-1α related mechanisms including CCL20 production in cigarette-smoke induced recruitment of dendritic cells and T cell activation in the mouse lung.
肺部先天免疫系统在慢性阻塞性肺疾病（COPD）的持续气道炎症和宿主防御受损中起着重要作用。患有 COPD 的患者的气道中浸润了各种免疫和炎症细胞，包括巨噬细胞、中性粒细胞、T 淋巴细胞和树突状细胞。虽然巨噬细胞、中性粒细胞和 T 淋巴细胞的作用已经得到很好的描述，但树突状细胞在 COPD 发病机制中的作用仍处于新兴研究领域。Botelho 及其同事在本期《呼吸研究》杂志上发表的一篇论文研究了树突状细胞募集在香烟烟雾诱导的小鼠急性和慢性炎症中的重要性。健康肺实质和气道中的树突状细胞具有重要的哨兵功能，并调节免疫稳态。在炎症反应中，这些细胞的功能和迁移模式发生了显著改变，但潜在的机制尚不完全清楚。Botelho 及其同事在这里证明了 IL-1R1/IL-1α 相关机制（包括 CCL20 产生）在香烟烟雾诱导的树突状细胞募集和小鼠肺部 T 细胞激活中的重要性。
