Nakajima T, Osborn J, Rhee J G, Song C W
University of Minnesota Medical School, Department of Therapeutic Radiology, Mpls. 55455.
Int J Hyperthermia. 1990 Jan-Feb;6(1):1-14. doi: 10.3109/02656739009140800.
The changes in rat liver blood flow, caused by hyperthermia, were studied. The liver region of rats was heated with Thermotron IV, an experimental capacitive heating device utilizing 8 MHz RF, and the liver blood flow was measured with radioactive microspheres. Portal venous blood flow slightly decreased during 30 min heating of the liver at 41 degrees C and returned to control level after the heating. When the liver was heated at 43 degrees C, portal venous blood flow decreased initially by about 20%, but gradually returned to control level during the 30 min heating. Hepatic arterial blood flow increased slightly during 30 min heating at 41 degrees C and 43 degrees C. Because almost 85% of the liver blood flow is portal venous blood flow, the change in total liver blood flow paralleled the change in portal venous blood flow. During regional heating of the liver the cardiac output declined significantly, which may account in part for the decrease in splanchnic blood flow, and thus portal venous blood flow. Changes in vascular resistance in the viscera may be another reason for the decrease in portal venous blood flow during heating of the liver region.
研究了热疗引起的大鼠肝脏血流变化。用Thermotron IV（一种利用8 MHz射频的实验性电容加热装置）加热大鼠的肝脏区域，并用放射性微球测量肝脏血流。在41℃加热肝脏30分钟期间，门静脉血流略有下降，加热后恢复到对照水平。当肝脏在43℃加热时，门静脉血流最初下降约20%，但在30分钟加热期间逐渐恢复到对照水平。在41℃和43℃加热30分钟期间，肝动脉血流略有增加。由于几乎85%的肝脏血流是门静脉血流，肝脏总血流的变化与门静脉血流的变化平行。在肝脏区域加热期间，心输出量显著下降，这可能部分解释了内脏血流的减少，进而导致门静脉血流减少。内脏血管阻力的变化可能是肝脏区域加热期间门静脉血流减少的另一个原因。
