Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309, USA.
Nat Rev Mol Cell Biol. 2012 Oct;13(10):607-25. doi: 10.1038/nrm3440. Epub 2012 Sep 20.
The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca(2+) signalling and the control of mitochondrial biogenesis and intracellular trafficking.
最具特征的细胞器接触位点是内质网 (ER) 和线粒体之间的接触位点。人们越来越了解 ER-线粒体接触位点是如何组织的，以及哪些因素汇聚在这个界面上，其中一些因素可能具有连接功能。ER-线粒体连接在协调这两个细胞器的功能中的作用也越来越清楚，它被证明参与了脂质合成、Ca(2+)信号转导以及线粒体生物发生和细胞内运输的控制的调节。
