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[环嘌呤核苷酸与介质物质对皮层神经元相互作用的微离子电泳研究]

[Microionophoretic study of interaction of cyclic purine nucleotides and mediator substances on the cortical neurons].

作者信息

Sherstnev I A, Svemtlaev I A

出版信息

Biull Eksp Biol Med. 1979 Sep;88(9):262-5.

PMID:229928
Abstract

Statistically significant data indicating selective interaction of noradenaline and cAMP as well as of acetylcholine and cGMP were obtained in experiments on the microionophoretic bringing of cyclic purine nucleotides and mediator substances acetylcholine and noradrenaline to the rabbit cortical neurons. Studies on the relationships between cAMP and cGMP at the single unit level suggest their multilevel functional interaction with other systems of intracellular regulators.

摘要

在对家兔皮层神经元进行环嘌呤核苷酸以及介质物质乙酰胆碱和去甲肾上腺素的微量离子导入实验中,获得了具有统计学意义的数据,表明去甲肾上腺素与环磷酸腺苷(cAMP)以及乙酰胆碱与环磷酸鸟苷(cGMP)之间存在选择性相互作用。在单细胞水平上对cAMP和cGMP之间关系的研究表明,它们与细胞内调节因子的其他系统存在多层次的功能相互作用。

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