Integrative activity of the neuron: the specific characteristics and plasticity of systemic mechanisms.

The notions of P. K. Anokhin regarding the integrative activity of neurons through the time course of the systemic organization of behavioral acts are developed in this article. It is shown that in the systemic organization of behavioral acts neurons in their activity not only initial motivations and reinforcement, but demonstrate anticipatory reactions on the basis of preceding reinforcements, including themselves in the formation of the apparatus of the acceptor of the result of an action. A dominant motivation substantially alters the sensitivity of brain neurons to neuromediators and neuropeptides. Change in the chemical sensitivity of neurons has been identified through the time course of the organization of the various stages of systemic organization of behavioral acts. It has been established that the sensitivity of neurons to motivational and sensory influences, as well as to biologically active substances is also determined to a substantial degree by their protein-synthesizing apparatus. Investigations have demonstrated the specific characteristics and plasticity of neurons in the systemic organization of behavioral acts.