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Ghrelin: a new treatment for non-alcoholic fatty liver disease?

作者信息

Delhanty Patric J D, van der Lely Aart J

出版信息

Endocrine. 2013 Apr;43(2):247-8. doi: 10.1007/s12020-012-9800-2. Epub 2012 Sep 20.

DOI:10.1007/s12020-012-9800-2
PMID:22992889
Abstract
摘要

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2
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3
High-fat diet with acyl-ghrelin treatment leads to weight gain with low inflammation, high oxidative capacity and normal triglycerides in rat muscle.高脂肪饮食联合酰基化 ghrelin 处理可导致大鼠肌肉体重增加、炎症反应低、氧化能力高且甘油三酯正常。
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Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation.脑肠肽 Obestatin 通过抑制摄食、增强肝脂联素信号和阻止胃饥饿素酰化来保护并逆转大鼠非酒精性脂肪性肝病及其相关的胰岛素抵抗。
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引用本文的文献

1
Non-alcoholic fatty liver disease: a diabetologist's perspective.非酒精性脂肪性肝病：糖尿病学家的视角。
Endocrine. 2014 Apr;45(3):344-53. doi: 10.1007/s12020-013-0087-8. Epub 2013 Nov 28.
2
Circulating glucagon to ghrelin ratio as a determinant of insulin resistance in hyperthyroidism.循环胰高血糖素与 ghrelin 比值作为甲状腺功能亢进症胰岛素抵抗的决定因素。
Endocrine. 2014 Feb;45(1):106-13. doi: 10.1007/s12020-013-9951-9. Epub 2013 Apr 10.

本文引用的文献

1
Mechanisms in endocrinology: Ghrelin: the differences between acyl- and des-acyl ghrelin.内分泌学机制：生长激素释放肽：酰化和去酰化生长激素释放肽的区别。
Eur J Endocrinol. 2012 Nov;167(5):601-8. doi: 10.1530/EJE-12-0456. Epub 2012 Aug 16.
2
Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver.脂肪肝作为胰岛素抵抗的后果和原因：2 型糖尿病肝脏的教训。
Endocr J. 2012;59(9):745-63. doi: 10.1507/endocrj.ej12-0228. Epub 2012 Aug 12.
3
Liver transplantation in nonalcoholic steatohepatitis is associated with high mortality and post-transplant complications: a single-center experience.
非酒精性脂肪性肝炎患者行肝移植术后死亡率和移植后并发症发生率高：单中心经验。
Digestion. 2012;86(2):107-13. doi: 10.1159/000339344. Epub 2012 Jul 27.
4
Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development.给予 ghrelin 可改善非酒精性脂肪性肝病发展过程中和发展后期间的炎症、氧化应激和细胞凋亡。
Endocrine. 2013 Apr;43(2):376-86. doi: 10.1007/s12020-012-9761-5. Epub 2012 Jul 29.
5
Management of nonalcoholic steatohepatitis: an evidence-based approach.非酒精性脂肪性肝炎的治疗：循证方法。
Clin Liver Dis. 2012 Aug;16(3):631-45. doi: 10.1016/j.cld.2012.05.003. Epub 2012 Jun 20.
6
Phenotyping the effect of diet on non-alcoholic fatty liver disease.表型分析饮食对非酒精性脂肪性肝病的影响。
J Hepatol. 2012 Dec;57(6):1370-3. doi: 10.1016/j.jhep.2012.07.003. Epub 2012 Jul 11.
7
Is it appropriate to study blood ghrelin and obestatin in non-alcoholic fatty liver disease (NAFLD) without using protease inhibitors?在不使用蛋白酶抑制剂的情况下研究非酒精性脂肪性肝病（NAFLD）中的血液胃饥饿素和肥胖抑制素是否合适？
Ann Hepatol. 2012 Jan-Feb;11(1):145-6.
8
Association of obestatin, ghrelin, and inflammatory cytokines in obese patients with non-alcoholic fatty liver disease.肥胖症患者非酒精性脂肪性肝病中肥胖素、ghrelin 和炎性细胞因子的相关性。
Obes Surg. 2011 Nov;21(11):1750-7. doi: 10.1007/s11695-011-0475-1.
9
Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice.未酰化生长素迅速调节 GHSR 缺失小鼠代谢活跃组织中的脂肪生成和胰岛素信号通路基因表达。
PLoS One. 2010 Jul 26;5(7):e11749. doi: 10.1371/journal.pone.0011749.
10
High ghrelin and obestatin levels and low risk of developing fatty liver.高胃饥饿素和肥胖抑制素水平与低脂肪肝发病风险相关。
Ann Hepatol. 2010 Jan-Mar;9(1):52-7.