良性出血性疾病放疗后的心血管死亡。镭hemmet子宫病队列研究（1912 - 1977年）

Cardiovascular death after radiotherapy for benign bleeding disorders. The Radiumhemmet metropathia cohort 1912-1977.

作者信息

Ryberg M, Nilsson B, Pettersson F

机构信息

Department of Gynaecological Oncology, Radiumhemmet, Karolinska sjukhuset, Stockholm, Sweden.

出版信息

J Intern Med. 1990 Feb;227(2):95-9. doi: 10.1111/j.1365-2796.1990.tb00125.x.

DOI:10.1111/j.1365-2796.1990.tb00125.x

PMID:2299307

Abstract

Of 788 women treated with ionizing irradiation for benign bleeding disorders (metropathia) 308 (39%) died of cardiovascular disease. In a control group, consisting of 1219 women with metropathia who were not irradiated, 257 (21%) cardiovascular deaths occurred. Although the risk of cardiovascular death in the two studied cohorts compared with national death rates was only 0.92 (lower limit 0.82; upper limit 1.03) and 0.88 (lower limit 0.78; upper limit 0.99) respectively, it was found that women irradiated before the menopause (age 50 years) run a higher risk of cardiovascular death than the controls in the same age group and those irradiated after the menopause.

摘要

在788名因良性出血性疾病（子宫病）接受电离辐射治疗的女性中，有308人（39%）死于心血管疾病。在由1219名未接受辐射的子宫病女性组成的对照组中，发生了257例（21%）心血管疾病死亡病例。尽管与全国死亡率相比，两个研究队列中心血管疾病死亡风险分别仅为0.92（下限0.82；上限1.03）和0.88（下限0.78；上限0.99），但研究发现，绝经前（50岁）接受辐射的女性比同年龄组的对照组女性以及绝经后接受辐射的女性面临更高的心血管疾病死亡风险。