HER2 阳性原发性乳腺癌患者 VEGFA 种系多态性的预后影响。
Prognostic impact of VEGFA germline polymorphisms in patients with HER2-positive primary breast cancer.
机构信息
Department of Oncology, Vejle Hospital, Vejle, Denmark.
出版信息
Anticancer Res. 2012 Sep;32(9):3619-27.
BACKGROUND
Vascular endothelial growth factor A (VEGFA) is essential in tumour angiogenesis, and polymorphisms in the VEGFA gene have been associated with breast cancer prognosis. The human epidermal growth factor receptor 2 (HER2) is overexpressed in breast tumours and is also associated with angiogenesis. We investigated the possible prognostic impact of VEGFA single nucleotide polymorphisms (SNPs) in patients with HER2-positive primary breast cancer.
PATIENTS AND METHODS
DNA was isolated from venous blood samples from 116 HER2-positive patients and genotyped for VEGFA -2578C>A, -1498T>C, -1154G>A, -634G>C, -7C>T and +936C>T SNPs using the TaqMan® SNP Genotyping Assay.
RESULTS
The -2578C>A and -634G>C genotypes were associated with tumour size, p ≤ 0.014. In univariate analysis -2578CC, -634CC and -7CC genotypes were associated with inferior recurrence-free survival (p ≤ 0.028) but in cox multivariate analysis, only the -634CC genotype remained an independent prognostic factor (p=0.008).
CONCLUSION
The VEGFA -634CC genotype was found to be associated with an inferior prognosis for patients with HER2-positive breast cancer.
背景
血管内皮生长因子 A（VEGFA）在肿瘤血管生成中至关重要，并且 VEGFA 基因的多态性与乳腺癌的预后相关。人类表皮生长因子受体 2（HER2）在乳腺癌中过表达，也与血管生成有关。我们研究了 VEGFA 单核苷酸多态性（SNPs）在 HER2 阳性原发性乳腺癌患者中的可能预后影响。
患者和方法
从 116 名 HER2 阳性患者的静脉血样中分离出 DNA，并使用 TaqMan® SNP Genotyping Assay 对 VEGFA-2578C>A、-1498T>C、-1154G>A、-634G>C、-7C>T 和 +936C>T SNPs 进行基因分型。
结果
-2578C>A 和-634G>C 基因型与肿瘤大小相关，p≤0.014。在单因素分析中，-2578CC、-634CC 和-7CC 基因型与较差的无复发生存率相关（p≤0.028），但在 cox 多因素分析中，只有-634CC 基因型仍然是一个独立的预后因素（p=0.008）。
结论
VEGFA-634CC 基因型与 HER2 阳性乳腺癌患者的预后较差相关。
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