DNA结合抑制因子-1蛋白在子宫内膜癌肿瘤进展中的作用与血管生成相关。
Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers.
作者信息
Maw Min Khine, Fujimoto Jiro, Tamaya Teruhiko
机构信息
Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, Gifu 501-1194, Japan.
出版信息
Exp Ther Med. 2010 Mar;1(2):351-356. doi: 10.3892/etm_00000055. Epub 2010 Mar 1.
The inhibitor of DNA binding (ID)-1 protein, an inhibitor of basic helix-loop-helix transcription factors, has been found to be involved in multiple cellular functions. In the present study, ID-1 histoscores and mRNA levels were both significantly (p<0.05) increased in uterine endometrial cancers according to clinical stage, histological grade and depth of myometrial invasion. Furthermore, the 60-month survival rate of the 25 patients with high ID-1 was poor (52%), while that of the other 25 patients with low ID-1 was significantly higher (80%) (p<0.05). ID-1 histoscores and mRNA levels significantly (p<0.0001) correlated with microvessel counts in uterine endometrial cancers. Therefore, ID-1 acts on tumor advancement via angiogenic activity and can be considered a candidate prognostic indicator in uterine endometrial cancers.
DNA结合抑制因子（ID）-1蛋白是一种碱性螺旋-环-螺旋转录因子的抑制因子，已被发现参与多种细胞功能。在本研究中，根据临床分期、组织学分级和肌层浸润深度，子宫内膜癌中ID-1组织学评分和mRNA水平均显著升高（p<0.05）。此外，25例ID-1高表达患者的60个月生存率较低（52%），而另外25例ID-1低表达患者的生存率则显著较高（80%）（p<0.05）。ID-1组织学评分和mRNA水平与子宫内膜癌中的微血管计数显著相关（p<0.0001）。因此，ID-1通过血管生成活性作用于肿瘤进展，可被视为子宫内膜癌的候选预后指标。
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