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本文引用的文献

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Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers.DNA结合抑制因子（ID）-1蛋白作为血管生成介质在子宫颈癌肿瘤进展中的表达
Br J Cancer. 2008 Nov 18;99(10):1557-63. doi: 10.1038/sj.bjc.6604722. Epub 2008 Oct 28.
2
Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma.Id-1和Id-2是食管鳞状细胞癌转移和预后的标志物。
Br J Cancer. 2007 Nov 19;97(10):1409-15. doi: 10.1038/sj.bjc.6604035. Epub 2007 Nov 13.
3
Id-1 overexpression in invasive ductal carcinoma cells is significantly associated with intratumoral microvessel density in ER-negative/node-positive breast cancer.浸润性导管癌细胞中Id-1的过表达与雌激素受体阴性/淋巴结阳性乳腺癌的瘤内微血管密度显著相关。
Cancer Lett. 2006 Dec 8;244(2):203-10. doi: 10.1016/j.canlet.2005.12.016. Epub 2006 Feb 8.
4
Id-1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer.舒林酸硫化物对Id-1基因的下调作用及其在胃癌肿瘤发展过程中的上调作用。
Int J Cancer. 2006 Mar 15;118(6):1356-63. doi: 10.1002/ijc.21503.
5
Genes that mediate breast cancer metastasis to lung.介导乳腺癌转移至肺部的基因。
Nature. 2005 Jul 28;436(7050):518-24. doi: 10.1038/nature03799.
6
Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF).前列腺癌细胞中Id-1的过表达通过激活血管内皮生长因子（VEGF）促进血管生成。
Carcinogenesis. 2005 Oct;26(10):1668-76. doi: 10.1093/carcin/bgi128. Epub 2005 May 19.
7
Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cells.Id1基因在甲状腺增生性和肿瘤性组织中表达上调，并调节甲状腺癌细胞的生长和分化。
J Clin Endocrinol Metab. 2004 Dec;89(12):6105-11. doi: 10.1210/jc.2004-1234.
8
Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix-loop-helix protein Id1.螺旋-环-螺旋蛋白Id1对乳腺上皮细胞中细胞周期蛋白表达和细胞周期进程的调控
Oncogene. 2005 Jan 13;24(3):381-9. doi: 10.1038/sj.onc.1208188.
9
Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression.Id-1和Id-2蛋白作为人类前列腺癌进展的分子标志物。
Clin Cancer Res. 2004 Mar 15;10(6):2044-51. doi: 10.1158/1078-0432.ccr-03-0933.
10
Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers.Id-1的过表达与人类胰腺癌中的肿瘤血管生成显著相关。
Br J Cancer. 2004 Mar 22;90(6):1198-203. doi: 10.1038/sj.bjc.6601684.

DNA结合抑制因子-1蛋白在子宫内膜癌肿瘤进展中的作用与血管生成相关。

Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers.

作者信息

Maw Min Khine, Fujimoto Jiro, Tamaya Teruhiko

机构信息

Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, Gifu 501-1194, Japan.

出版信息

Exp Ther Med. 2010 Mar;1(2):351-356. doi: 10.3892/etm_00000055. Epub 2010 Mar 1.

DOI:10.3892/etm_00000055
PMID:22993548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3445945/
Abstract

The inhibitor of DNA binding (ID)-1 protein, an inhibitor of basic helix-loop-helix transcription factors, has been found to be involved in multiple cellular functions. In the present study, ID-1 histoscores and mRNA levels were both significantly (p<0.05) increased in uterine endometrial cancers according to clinical stage, histological grade and depth of myometrial invasion. Furthermore, the 60-month survival rate of the 25 patients with high ID-1 was poor (52%), while that of the other 25 patients with low ID-1 was significantly higher (80%) (p<0.05). ID-1 histoscores and mRNA levels significantly (p<0.0001) correlated with microvessel counts in uterine endometrial cancers. Therefore, ID-1 acts on tumor advancement via angiogenic activity and can be considered a candidate prognostic indicator in uterine endometrial cancers.

摘要

DNA结合抑制因子（ID）-1蛋白是一种碱性螺旋-环-螺旋转录因子的抑制因子，已被发现参与多种细胞功能。在本研究中，根据临床分期、组织学分级和肌层浸润深度，子宫内膜癌中ID-1组织学评分和mRNA水平均显著升高（p<0.05）。此外，25例ID-1高表达患者的60个月生存率较低（52%），而另外25例ID-1低表达患者的生存率则显著较高（80%）（p<0.05）。ID-1组织学评分和mRNA水平与子宫内膜癌中的微血管计数显著相关（p<0.0001）。因此，ID-1通过血管生成活性作用于肿瘤进展，可被视为子宫内膜癌的候选预后指标。