在胚胎斑马鱼中具有可变命运的一个已鉴定运动神经元。
An identified motoneuron with variable fates in embryonic zebrafish.
作者信息
Eisen J S, Pike S H, Romancier B
机构信息
Institute of Neuroscience, University of Oregon, Eugene 97403.
出版信息
J Neurosci. 1990 Jan;10(1):34-43. doi: 10.1523/JNEUROSCI.10-01-00034.1990.
Every trunk hemisegment of the zebrafish is innervated by 3 identified primary motoneurons whose development can be observed directly in living embryos. In this paper, we describe another identified neuron that is part of this system. Unlike the other primary motoneurons which are present in all trunk hemisegments, this cell is present in slightly less than half of the trunk hemisegments. Additionally, this cell has at least 2 different fates: it may become a primary motoneuron and arborize in an exclusive muscle territory, or it may die during embryonic development. We have named this cell VaP, for variable primary. We show that the presence of VaP does not affect the early development of the other primary motoneurons in the same hemisegment. Moreover, we show that ablation of both VaP and caudal primary does not alter pathfinding by another identified primary motoneuron.
斑马鱼的每个躯干半节段都由3个已确定的初级运动神经元支配，其发育过程可在活胚胎中直接观察到。在本文中，我们描述了该系统中的另一个已确定的神经元。与存在于所有躯干半节段的其他初级运动神经元不同，这个细胞存在于略少于一半的躯干半节段中。此外，这个细胞至少有2种不同的命运：它可能成为一个初级运动神经元并在一个特定的肌肉区域形成分支，或者在胚胎发育过程中死亡。我们将这个细胞命名为VaP，即可变初级（Variable primary）。我们发现VaP的存在并不影响同一半节段中其他初级运动神经元的早期发育。此外，我们还表明，去除VaP和尾侧初级运动神经元并不会改变另一个已确定的初级运动神经元的路径寻找。
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