Department of Neurosurgery, Fukuoka University, Fukuoka, Japan.
Neuropathology. 2013 Jun;33(3):306-11. doi: 10.1111/j.1440-1789.2012.01350.x. Epub 2012 Sep 21.
We present a case of a 53-year-old HIV negative man with a 2-month history of progressive recent memory disturbance, gait disturbance and urinary incontinence. On MRI, an infiltrative tumor in the brain and spinal cord was noted. Subsequent positron emission tomography studies along with bone marrow biopsy and serum protein electrophoresis showed no evidence of systemic disease. Open brain biopsy results revealed a small lymphocytic infiltrate with scattered plasma cells in a predominantly perivascular growth pattern. The morphology was consistent with involvement by a low-grade B-cell lymphoma. Immunohistochemical findings showed CD20+, CD10-, CD5-, TdT-, EBV-encoded RNA in situ- and IgM-. The above findings were consistent with involvement by a non-dural extranodal marginal zone B-cell lymphoma (MZBCL) primary to the brain and spinal cord. This is a case report of a CNS MZBCL of mucosa-associated lymphoid tissue type involving the brain and spinal cord parenchyma.
我们报告了一例 53 岁 HIV 阴性男性，有 2 个月的近期记忆障碍、步态障碍和尿失禁进行性加重病史。MRI 显示脑和脊髓有浸润性肿瘤。随后的正电子发射断层扫描研究以及骨髓活检和血清蛋白电泳显示无全身疾病证据。开放性脑活检结果显示小淋巴细胞浸润，伴浆细胞散在，主要呈血管周围生长模式。形态学符合低度 B 细胞淋巴瘤受累。免疫组化结果显示 CD20+、CD10-、CD5-、TdT-、EBV 编码 RNA 原位和 IgM-。上述发现符合脑和脊髓原发性非脑膜结外黏膜相关淋巴组织型边缘区 B 细胞淋巴瘤（MZBCL）。这是一例脑和脊髓实质受累的中枢神经系统 MZBCL 病例报告，为黏膜相关淋巴组织型。
