Papanicolau-Sengos Antonios, Wang-Rodriguez Jessica, Wang Huan-You, Lee Roland R, Wong Anna, Hansen Lawrence A, Mahooti Sepi, Rashidi Hooman H
Department of Pathology, University of California San Diego School of Medicine and Veteran Administration Medical Center of San Diego, 9500 Gilman Drive # 9113, La Jolla, CA 92093-9113, USA.
Int J Clin Exp Pathol. 2012;5(1):89-95. Epub 2012 Jan 1.
We present a case of a 70-year-old HIV negative man with a five-year history of progressive dysnomia and new onset right extremity numbness, dysarthria, and blurry vision. On magnetic resonance imaging (MRI), an infiltrative enhancing tumor was noted. Follow up brain biopsy results revealed a small lymphocytic infiltrate with scattered plasma cells in a predominantly perivascular growth pattern. Flow-cytometric findings revealed a lambda monotypic B-cell population. The morphology and the flow cytometric findings were consistent with involvement by a low grade B-cell lymphoma. Subsequent positron emission tomography (PET) studies along with bone marrow biopsy and serum protein electrophoresis showed no evidence of systemic disease. The above findings are consistent with involvement by a non-dural extranodal marginal zone B-cell lymphoma (MZBCL) primary to the central nervous system (CNS). This is the first reported case of a primary CNS MZBCL with flow cytometric analysis. A review of literature on this rare entity is also included.
我们报告一例70岁HIV阴性男性，有5年进行性命名障碍病史，新发右侧肢体麻木、构音障碍和视力模糊。磁共振成像（MRI）显示有一个浸润性强化肿瘤。后续脑活检结果显示，以血管周围生长为主的模式中有少量淋巴细胞浸润及散在浆细胞。流式细胞术结果显示为λ单克隆B细胞群。形态学和流式细胞术结果与低度B细胞淋巴瘤累及相符。随后的正电子发射断层扫描（PET）研究以及骨髓活检和血清蛋白电泳均未显示有全身疾病的证据。上述发现与中枢神经系统（CNS）原发性非硬脑膜结外边缘区B细胞淋巴瘤（MZBCL）累及相符。这是首例经流式细胞术分析的原发性CNS MZBCL病例。本文还包括对该罕见实体的文献综述。
