School of Public Health, Faculty of Welfare and Health Sciences, University of Haifa, Haifa, Israel Israel.
Int J Clin Pract. 2012 Oct;66(10):948-58. doi: 10.1111/j.1742-1241.2012.02966.x.
The objective of the study was to examine the impact of WWII-related caloric restriction (CR) on subsequent breast cancer (BC) risk based on individual exposure experiences and whether this effect was modified by age at exposure.
We compared 65 breast cancer patients diagnosed between 2005-2010 to 200 controls without breast cancer who were all members of various organizations for Jewish WWII survivors in Israel. All participants were Jewish women born in Europe prior to 1945 who lived at least 6 months under Nazi rule during WWII and immigrated to Israel after the war. We estimated CR using a combined index for hunger and used logistic regression models to estimate the association between CR and BC, adjusting for potential confounders.
Women who were severely exposed to hunger had an increased risk of BC (OR=5.0, 95% CI= 2.3-10.8) compared to women who were mildly exposed. The association between CR and BC risk was stronger for women who were exposed at a younger age (0-7 years) compared to the risk of BC in women exposed at ≥ 14 years (OR= 2.8, 95% CI=1.3-6.3).
Severe exposure to CR is associated with a higher risk for BC decades later, and may be generalized to other cases of severe starvation during childhood that may have long-term effects on cancer in adulthood.
本研究旨在根据个体暴露经历，探讨二战期间热量限制（CR）对随后乳腺癌（BC）风险的影响，并探讨这种影响是否受暴露年龄的影响。
我们比较了 2005-2010 年间诊断出的 65 例乳腺癌患者与 200 例无乳腺癌的对照组，对照组均为以色列各种犹太二战幸存者组织的成员。所有参与者均为 1945 年前出生于欧洲的犹太女性，在二战期间至少有 6 个月生活在纳粹统治下，并在战后移民到以色列。我们使用饥饿综合指数来估计 CR，并使用逻辑回归模型来估计 CR 与 BC 之间的关联，同时调整了潜在的混杂因素。
与轻度暴露的女性相比，严重暴露于饥饿的女性患 BC 的风险增加（OR=5.0，95%CI=2.3-10.8）。与≥14 岁暴露的女性相比，CR 与 BC 风险之间的关联在年轻（0-7 岁）暴露的女性中更强（OR=2.8，95%CI=1.3-6.3）。
严重暴露于 CR 与数十年后更高的 BC 风险相关，并且可能推广到其他儿童时期严重饥饿的情况，这可能对成年期的癌症产生长期影响。
