Emmy Noether Research Group, Institute of Pathology, University of Technology Dresden, Germany.
High Alt Med Biol. 2012 Sep;13(3):162-8. doi: 10.1089/ham.2012.1043.
Hypoxia-mediated regulation of stem cell fate, or reduced oxygen availability, is a prominent feature during mammalian development and under physiological and pathological conditions in adults. Oxygen-sensing is therefore indispensable as it enables the cells to adapt instantaneously to an inappropriate pO(2). This machinery relies primarily on hypoxia inducible factor (HIF). Moreover, a growing body of evidence proposes that different types of stem cells exist in a very hypoxic microenvironment, which may be beneficial for the maintenance of these cells and ensures continuous replenishment of dead or damaged cells in virtually all tissues of the body. Recent reports have shown that HIF is a critical player in these responses. However, a better understanding of the different HIF-related mechanisms is of utmost importance for the improvement of therapeutic strategies for tissue regeneration as well as hematological malignancies.
低氧介导的干细胞命运调控，或氧供应减少，是哺乳动物发育过程中的一个显著特征，也是成人在生理和病理条件下的一个显著特征。因此，氧感应是必不可少的，因为它使细胞能够即时适应不合适的 pO2。这一机制主要依赖于缺氧诱导因子 (HIF)。此外，越来越多的证据表明，不同类型的干细胞存在于非常低氧的微环境中，这可能有利于这些细胞的维持，并确保在身体几乎所有组织中不断补充死亡或受损的细胞。最近的报告表明，HIF 是这些反应的关键参与者。然而，更好地理解不同的 HIF 相关机制对于改善组织再生和血液恶性肿瘤的治疗策略至关重要。
