Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.
Curr Opin Cell Biol. 2012 Apr;24(2):232-5. doi: 10.1016/j.ceb.2012.01.005. Epub 2012 Jan 30.
Hypoxia, a condition of insufficient oxygen availability, occurs during normal development as well as tumorigenesis. Cellular responses to hypoxia are primarily mediated by hypoxia-inducible factors (HIFs). Recent studies have revealed that dormant hematopoietic stem cells (HSCs) reside within hypoxic regions of the bone marrow and that HIF is a critical player in HSC homeostasis. The functional significance of HIF in maintaining stemness also applies to cancer stem cells in hematological malignancies. These findings indicate that better understanding of the mechanisms underlying HIF functions in stem cells should permit the development of new therapies for tissue regeneration and cancer.
缺氧是一种氧气供应不足的情况，它既发生在正常发育过程中，也发生在肿瘤发生过程中。细胞对缺氧的反应主要是由缺氧诱导因子（HIFs）介导的。最近的研究表明，休眠的造血干细胞（HSCs）存在于骨髓的缺氧区域，HIF 是 HSC 动态平衡的关键因素。HIF 在维持干细胞干性方面的功能意义也适用于血液恶性肿瘤中的癌症干细胞。这些发现表明，更好地理解 HIF 在干细胞中的功能机制，应该能够为组织再生和癌症的新疗法的发展提供帮助。
