Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Bochum, Germany.
J Toxicol Environ Health A. 2012;75(19-20):1232-40. doi: 10.1080/15287394.2012.709375.
Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) and polychlorinated biphenyls (PCB) are postulated to act as endocrine disrupters. In the ongoing Duisburg birth cohort study, started in 2000-2002, influence of persistent organic pollutants (POP) on child development was monitored. For the first time, associations were reported between prenatal and postnatal PCDD/F and PCB exposures and early endocrinological changes concerning adrenarchal development. PCDD/F and PCB concentrations were measured in blood samples taken in wk 32 of pregnancy and in breast milk using gas chromatography and high-resolution mass spectrometry (GC/HRMS). At the age of 6-7 and 8-9 yr, serum samples were collected from 111 children. The samples were assayed for the sex hormones testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), and 17-OH-progesterone (17-OHP) by using an automated chemiluminescence assay system. Analyses of repeated measurements of DHEA-S serum levels were performed by linear regression analysis using generalized estimating equations (GEE). Linear regression analysis showed a positive association between DHEA-S and breast milk levels of PCDD/F and PCB expressed as toxicity equivalents according to toxicity equivalent factors published by the World Health Organization (WHO) in 2005 (WHO(2005)-TEq) (increase of 29%, geometric mean ratio, GMR: 1.29, 95% CI 1.06-1. 58 per doubling of PCDD/F + PCB WHO(2005)-TEq levels). Results for the association with the WHO(2005)-TEq levels in blood of mothers were in the same direction (increase of 15%, GMR 1.15, 95% CI 0.93-1.42 per doubling of PCDD/F + PCB WHO(2005)-TEq levels), but not significant. Data indicate that PCDD/F and PCB exposure in infancy may influence DHEA-S serum levels in prepubertal children. Increased DHEA-S serum levels are considered to indicate acceleration of the adrenal maturation.
多氯二苯并对二恶英和二苯并呋喃（PCDD/F）和多氯联苯（PCB）被认为是内分泌干扰物。在正在进行的杜伊斯堡出生队列研究中，该研究始于 2000-2002 年，监测了持久性有机污染物（POP）对儿童发育的影响。首次报告了产前和产后 PCDD/F 和 PCB 暴露与青春期前肾上腺发育的早期内分泌变化之间的关联。使用气相色谱和高分辨率质谱（GC/HRMS）在妊娠第 32 周和母乳中测量了 PCDD/F 和 PCB 浓度。在 6-7 岁和 8-9 岁时，从 111 名儿童中采集了血清样本。使用自动化化学发光分析系统检测了这些样本中的性激素睾酮、雌二醇、脱氢表雄酮硫酸酯（DHEA-S）和 17-羟孕酮（17-OHP）。通过使用广义估计方程（GEE）的线性回归分析对 DHEA-S 血清水平的重复测量进行了分析。线性回归分析显示，DHEA-S 与母乳中 PCDD/F 和 PCB 的水平呈正相关，这些水平根据世界卫生组织（世卫组织）在 2005 年公布的毒性等效因子表示为毒性等效物（增加 29%，几何均数比，GMR：1.29，95%CI 为 1.06-1.58，PCDD/F+PCB 世卫组织（2005）-TEq 水平每增加一倍）。与母亲血液中世卫组织（2005）-TEq 水平关联的结果方向相同（增加 15%，GMR 为 1.15，95%CI 为 0.93-1.42，PCDD/F+PCB 世卫组织（2005）-TEq 水平每增加一倍），但无统计学意义。数据表明，婴儿期的 PCDD/F 和 PCB 暴露可能会影响青春期前儿童的 DHEA-S 血清水平。DHEA-S 血清水平升高被认为表明肾上腺成熟加速。
