Department of Health and Socio-Medical Sciences, Biostatistics Unit, Faculty of Medicine, Alcalá University, Madrid, Spain.
J Clin Periodontol. 2012 Nov;39(11):1024-31. doi: 10.1111/jcpe.12000. Epub 2012 Sep 19.
The aim of this study was to evaluate the association of very low and low birth weight (VLBW and LBW) with maternal periodontitis.
Overall, 1206 women were examined at post-partum and two alternative criteria for periodontitis definition were used: (1) four or more teeth with at least one site with probing depth (PD) ≥ 4 mm and clinical attachment loss (CAL) ≥ 3 mm; and (2) at least one site with PD and CAL ≥ 4 mm. For each definition, two multivariate analyses were performed: (1) linear regression for birth weight; (2) ordinal logistic regression for birth weight, categorized as adequate (n = 1046), LBW (n = 145) and VLBW (n = 15).
Linear regression showed that maternal periodontitis was associated with a decrease in mean birth weight (periodontitis definition 1: p = 0.027; periodontitis definition 2: p = 0.003). Ordinal logistic regression showed that maternal periodontitis was associated with LBW and VLBW [odds ratio (OR) = 2.0; 95% confidence interval (CI) 1.39-2.90, when considering periodontitis definition 2]; and with LBW (OR = 1.65; 95% CI 1.15-2.36, when considering periodontitis definition 1).
Maternal periodontitis was associated with a decrease in mean birth weight, as well as with LBW and VLBW.
本研究旨在评估极低出生体重（VLBW）和低出生体重（LBW）与母体牙周炎的关联。
共有 1206 名女性在产后接受了检查，并使用了两种替代的牙周炎定义标准：（1）四颗或更多牙齿至少有一个部位的探诊深度（PD）≥4 毫米和临床附着丧失（CAL）≥3 毫米；（2）至少有一个部位的 PD 和 CAL≥4 毫米。对于每种定义，进行了两次多变量分析：（1）线性回归用于出生体重；（2）有序逻辑回归用于出生体重，分为适当体重（n=1046）、LBW（n=145）和 VLBW（n=15）。
线性回归显示，母体牙周炎与平均出生体重下降相关（牙周炎定义 1：p=0.027；牙周炎定义 2：p=0.003）。有序逻辑回归显示，母体牙周炎与 LBW 和 VLBW 相关[比值比（OR）=2.0；95%置信区间（CI）1.39-2.90，当考虑牙周炎定义 2 时]；与 LBW 相关（OR=1.65；95%CI 1.15-2.36，当考虑牙周炎定义 1 时）。
母体牙周炎与平均出生体重下降以及 LBW 和 VLBW 相关。
