Department of Health and Sociomedical Sciences, Biostatistics Unit, Faculty of Medicine, Alcalá University, Madrid, Spain.
J Periodontol. 2010 Mar;81(3):350-8. doi: 10.1902/jop.2009.090527.
Despite previous studies addressing the link between preterm or low birth weight infants and maternal periodontitis, extreme preterm births have received far less attention. This study is designed to address the possible association between maternal periodontal disease and preterm or extreme preterm birth.
Immediately after childbirth, 1,207 women underwent an examination in which periodontal disease was assessed according to two alternative definitions: 1) four or more teeth with at least one site showing probing depth (PD) >or=4 mm and clinical attachment loss (AL) >or=3 mm, and 2) at least one site showing PD and clinical AL >or=4 mm. For each of these definitions, two types of multivariate analysis were conducted: a linear regression analysis for the number of gestation weeks, and a more specific ordinal logistic regression analysis for the ordinal variable gestation time categorized as normal (term) (n = 1,046 women) or mild-moderate (n = 146 women) or extreme preterm (n = 15 women).
Periodontal disease was associated with fewer weeks of gestation by linear regression (definition 1: P = 0.012; definition 2: P <0.001) and with preterm (n = 161; mild-moderate and extreme) or extreme preterm births (n = 15) by ordinal logistic regression (definition 1: odds ratio [OR] = 1.83, 95% confidence interval [CI]: 1.28 to 2.62; definition 2: OR = 2.37, 95% CI: 1.62 to 3.46).
Our findings suggest that periodontal disease is associated with a premature or extremely premature birth.
尽管先前的研究已经探讨了早产儿或低出生体重儿与母体牙周炎之间的联系，但极早产儿出生的问题却很少受到关注。本研究旨在探讨母体牙周病与早产或极早产之间可能存在的关联。
在分娩后立即对 1207 名妇女进行了检查，根据两种替代定义评估了牙周病：1）四颗或更多牙齿至少有一个部位的探诊深度（PD）≥4mm 和临床附着丧失（AL）≥3mm，2）至少有一个部位的 PD 和临床 AL≥4mm。对于这两种定义，均进行了两种类型的多变量分析：线性回归分析孕周数，以及更具体的有序逻辑回归分析，将妊娠时间有序变量分为正常（足月）（n=1046 名妇女）或轻度-中度（n=146 名妇女）或极早产（n=15 名妇女）。
牙周病与线性回归的妊娠周数较少相关（定义 1：P=0.012；定义 2：P<0.001），与早产（n=161；轻度-中度和极早产）或极早产（n=15）的相关性通过有序逻辑回归（定义 1：比值比[OR] = 1.83，95%置信区间[CI]：1.28 至 2.62；定义 2：OR = 2.37，95% CI：1.62 至 3.46）。
我们的研究结果表明，牙周病与早产或极早产有关。
